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Titolo:
Age-dependency of (45)calcium accumulation following lateral fluid percussion: Acute and delayed patterns
Autore:
Osteen, CL; Moore, AH; Prins, ML; Hovda, DA;
Indirizzi:
Univ Calif Los Angeles, Sch Med, Div Neurosurg, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Univ Calif Los Angeles, Sch Med, Dept Physiol Sci, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Univ Calif Los Angeles, Sch Med, Brain Res Inst, Los Angeles, CA 90024 USAUniv Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Univ Calif Los Angeles, Sch Med, Dept Med & Mol Pharmacol, Los Angeles, CA90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA90024 USA
Titolo Testata:
JOURNAL OF NEUROTRAUMA
fascicolo: 2, volume: 18, anno: 2001,
pagine: 141 - 162
SICI:
0897-7151(200102)18:2<141:AO(AFL>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRAUMATIC BRAIN INJURY; EXCITATORY AMINO-ACIDS; CLOSED-HEAD-INJURY; CEREBRAL-ARTERY OCCLUSION; RAT-BRAIN; CALCIUM ACCUMULATION; POSTNATAL-DEVELOPMENT; CA-45 ACCUMULATION; NEURONAL DAMAGE; IMMATURE RAT;
Keywords:
calcium; calcium-45 autoradiography; delayed cell death; development; fluid percussion injury; rat; traumatic brain injury;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
101
Recensione:
Indirizzi per estratti:
Indirizzo: Osteen, CL Univ Calif Los Angeles, Sch Med, Div Neurosurg, Room 18-228,Box957039, Los Angeles, CA 90024 USA Univ Calif Los Angeles Room 18-228,Box 957039 Los Angeles CA USA 90024
Citazione:
C.L. Osteen et al., "Age-dependency of (45)calcium accumulation following lateral fluid percussion: Acute and delayed patterns", J NEUROTRAU, 18(2), 2001, pp. 141-162

Abstract

This study was designed to determine the regional and temporal profile of (45)calcium (Ca-45(2+)) accumulation following mild lateral fluid percussion (LFP) injury and how this profile differs when traumatic brain injury occurs early in life. Thirty-six postnatal day (P) 17, thirty-four P28, and 17adult rats were subjected to a mild (similar to2.75 atm) LFP or sham injury and processed for Ca-45(2+) autoradiography immediately, 6 h, and 1, 2, 4, 7, and 14 days after injury. Optical densities were measured bilaterally within 16 regions of interest. Ca-45(2+) accumulation was evident diffuselywithin the ipsilateral cerebral cortex immediately after injury (18-64% increase) in all ages, returning to sham levels by 2-4 days in P17s, I day inP28s, and 4 days in adults. While P17s showed no further Ca-45(2+) accumulation, P28 and adult rats showed an additional delayed, focal accumulation in the ipsilateral thalamus beginning 2-4 days postinjury (12-49% increase)and progressing out to 14 days (26-64% increase). Histological analysis ofcresyl violet-stained, fresh frozen tissue indicated little evidence of neuronal loss acutely tin all ages), but considerable delayed cell death in the ipsilateral thalamus of the P28 and adult animals. These data suggest that two temporal patterns of Ca-45(2+) accumulation exist following LFP: acute, diffuse calcium flux associated with the injury-induced ionic cascade and blood brain barrier breakdown and delayed, focal calcium accumulation associated with secondary cell death. The age-dependency of posttraumatic Ca-45(2+) accumulation may be attributed to differential biomechanical consequences of the LFP injury and/or the presence or lack of secondary cell death.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 07:21:28