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Titolo:
Alpha(2) receptor binding in the medulla oblongata in the sudden infant death syndrome
Autore:
Mansouri, J; Panigrahy, A; Filiano, JJ; Sleeper, LA; St John, WM; Kinney, HC;
Indirizzi:
Childrens Hosp, Dept Pathol, Boston, MA 02115 USA Childrens Hosp Boston MA USA 02115 osp, Dept Pathol, Boston, MA 02115 USA Harvard Univ, Sch Med, Boston, MA USA Harvard Univ Boston MA USAHarvard Univ, Sch Med, Boston, MA USA Childrens Hosp, Dept Neurol, Boston, MA 02115 USA Childrens Hosp Boston MA USA 02115 osp, Dept Neurol, Boston, MA 02115 USA Dartmouth Hitchcock Med Ctr, Childrens Hosp Dartmouth, Dept Pediat Intens Care Neurol, Lebanon, NH 03766 USA Dartmouth Hitchcock Med Ctr Lebanon NH USA 03766 l, Lebanon, NH 03766 USA New England Res Inst, Watertown, MA 02172 USA New England Res Inst Watertown MA USA 02172 Inst, Watertown, MA 02172 USA Dartmouth Med Sch, Dept Physiol, Lebanon, NH USA Dartmouth Med Sch Lebanon NH USA Med Sch, Dept Physiol, Lebanon, NH USA
Titolo Testata:
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
fascicolo: 2, volume: 60, anno: 2001,
pagine: 141 - 146
SICI:
0022-3069(200102)60:2<141:ARBITM>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS-TRACTUS-SOLITARIUS; BRAIN-STEM; ARCUATE NUCLEUS; NALOXONE BINDING; NEURONS; VICTIMS; RAT; APNEA;
Keywords:
autoresuscitation; intermediate reticular zone; receptor autoradiography; respiration; sudden infant death; vagal nuclei;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Kinney, HC Childrens Hosp, Dept Pathol, 300 Longwood Ave, Boston, MA 02115USA Childrens Hosp 300 Longwood Ave Boston MA USA 02115 A 02115 USA
Citazione:
J. Mansouri et al., "Alpha(2) receptor binding in the medulla oblongata in the sudden infant death syndrome", J NE EXP NE, 60(2), 2001, pp. 141-146

Abstract

The sudden infant death syndrome (SIDS) is the leading cause of postnatal infant mortality in the United States. Its etiology remains unknown. We propose that SIDS, or a subset of SIDS, is due to a failure of autoresuscitation, a protective brainstem response to asphyxia or hypoxia, in a vulnerableinfant during a critical developmental period. Gasping is an important component of autoresuscitation that is thought to be mediated by the "gasping center" in the lateral tegmentum of the medulla, a region homologous in itscytoarchitecture and chemical anatomy to the intermediate reticular zone (IRZ) in the human. Since we found that [H-3]para-aminoclonidine ([H-3]PAC) binding to alpha(2)-adrenergic receptors localizes to this region in human infants and, thereby provides a neurochemical marker for it, we tested the hypothesis that [H-3]PAC binding to alpha(2)-adrenergic receptors is decreased in the IRZ in SIDS victims. Using quantitative tissue autoradiography with [H-3]PAC as the radioligand and phentolamine as the displacer, we analyzed alph(2)-receptor binding density in the IRZ, as well as in 7 additionalsites for comparison, in 10 SIDS and 10 control medullae. There were no significant differences in alpha, receptor binding in the IRZ, vagal nuclei, or other medullary sites examined between SIDS and control cases. These results suggest that the putative gasping defect in the IRZ in SIDS victims isnot related to [H-3]PAC binding to alpha(2)-adrenergic receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:48:50