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Titolo:
Intrapallidal dopamine restores motor deficits induced by 6-hydroxydopamine in the rat
Autore:
Galvan, A; Floran, B; Erlij, D; Aceves, J;
Indirizzi:
Inst Politecn Nacl, Ctr Invest & Estud Avanzados, Dept Fisiol Biofis & Neurociencias, Mexico City, DF, Mexico Inst Politecn Nacl Mexico City DF Mexico encias, Mexico City, DF, Mexico Suny Downstate Med Ctr, Dept Physiol, Brooklyn, NY 11203 USA Suny Downstate Med Ctr Brooklyn NY USA 11203 siol, Brooklyn, NY 11203 USA
Titolo Testata:
JOURNAL OF NEURAL TRANSMISSION
fascicolo: 2, volume: 108, anno: 2001,
pagine: 153 - 166
SICI:
0300-9564(2001)108:2<153:IDRMDI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR MESSENGER-RNA; INSITU HYBRIDIZATION HISTOCHEMISTRY; RETICULAR THALAMIC NUCLEUS; GLOBUS-PALLIDUS; BASAL GANGLIA; SUBSTANTIA-NIGRA; SUBTHALAMIC NUCLEUS; BEHAVIORAL RECOVERY; PARKINSON-MODEL; INTRACEREBRAL INJECTIONS;
Keywords:
dopamine; dopamine D1 receptors; dopamine D2 receptors; GABA; globus pallidus; Parkinson's disease; turning behavior; staircase test;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Aceves, J IPN, CINVESTAV, Dept Physiol, Apartado Postal 14-740, Mexico City 07300, DF, Mexico IPN Apartado Postal 14-740 Mexico City DF Mexico 07300 F, Mexico
Citazione:
A. Galvan et al., "Intrapallidal dopamine restores motor deficits induced by 6-hydroxydopamine in the rat", J NEURAL TR, 108(2), 2001, pp. 153-166

Abstract

To explore whether dopamine deficits in the globus pallidus have a role ingenerating the motor symptoms of Parkinson's disease, we examined the effects of selective intrapallidal administration of dopamine or its antagonists in rats unilaterally lesioned with 6-hydroxydopamine into the medial forebrain bundle. Either the turning behavior induced by apomorphine or the deficit in the performance of a skilled forelimb-reaching task was used as assay for drug action. Microinjection of either the D2 receptor antagonist, sulpiride, or the D1 receptor antagonist, SCH-23390, into the dopamine-denervated pallidum significantly reduced apomorphine induced turning. In animalstrained to perform a skilled forelimb-reaching task, 6-OHDA lesions causeda marked motor deficit in the contralateral forelimb. Intrapallidal dopamine applied either intermittently or continuously, restored up to 50% of themotor performance. Continuous application promoted a motor recovery that outlasted dopamine administration. These results show that lack of dopamine in the GP plays an important role in generating the motor symptoms caused by lesion of dopaminergic pathways. Moreover, motor recovery was produced byselectively injecting dopamine into the globus pallidus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 14:42:04