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Titolo:
Light scattering experiments on aqueous solutions of selected cellulose ethers: contribution to the study of polymer-mineral interactions in a new injectable biomaterial
Autore:
Bohic, S; Weiss, P; Roger, P; Daculsi, G;
Indirizzi:
Fac Chirurg Dent Nantes, Ctr REch Mat Internet Biol, INSERM, E9903, F-44042 Nantes 01, France Fac Chirurg Dent Nantes Nantes France 01 9903, F-44042 Nantes 01, France INRA, Lab Biochim & Technol Glucides, F-44316 Nantes, France INRA NantesFrance F-44316 im & Technol Glucides, F-44316 Nantes, France
Titolo Testata:
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
fascicolo: 3, volume: 12, anno: 2001,
pagine: 201 - 205
SICI:
0957-4530(200103)12:3<201:LSEOAS>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
CALCIUM-PHOSPHATE CERAMICS; THERMAL GELATION; METHYLCELLULOSE; THERMOGELATION; SUBSTITUTE; COMPOSITE; WATER; BONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Bohic, S Fac Chirurg Dent Nantes, Ctr REch Mat Internet Biol, INSERM, E9903, 1 Pl ARicordeau, F-44042 Nantes 01, France Fac Chirurg Dent Nantes 1 Pl A Ricordeau Nantes France 01 France
Citazione:
S. Bohic et al., "Light scattering experiments on aqueous solutions of selected cellulose ethers: contribution to the study of polymer-mineral interactions in a new injectable biomaterial", J MAT S-M M, 12(3), 2001, pp. 201-205

Abstract

Hydroxypropylmethylcellulose (HPMC) is used as a ligand for a bioactive calcium phosphate ceramic (the filler) in a ready-to-use injectable sterilized biomaterial for bone and dental surgery. Light scattering experiments were usually used to study high water-soluble polymers and to determine the basic macromolecular parameters. In order to gain a deeper understanding of polymer/mineral interactions in this type of material, we have investigated the effect of divalent and trivalent ions (Ca2+, PO43-) and steam sterilization on dilute solutions of HPMC and hydroxyethylcellulose (HEC). The sterilization process may cause some degradation of HEC taking into account its high molecular weight and some rigidity of the polymer chain. Moreover, in the case of HPMC, the changes in the conformations rather than degradation process are supposed. These effects of degradation and flocculation are strengthened in alkaline medium. Experimental data suggested the formation of chelate complexes between Ca2+ and HPMC which improve its affinity to the mineral blend and consolidate the injectable biomaterial even in the case ofits hydration by biological fluid. (C) 2001 Kluwer Academic Publishers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:18:23