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Titolo:
Radiosynthesis of a ligand for studying the glycine transporter: [C-11]ALX-5407
Autore:
Ravert, HT; Mathews, WB; Klitenick, MA; Wong, DF; Dannals, RF;
Indirizzi:
Johns Hopkins Med Inst, Dept Radiol, Div Nucl Med, Baltimore, MD 21287 USAJohns Hopkins Med Inst Baltimore MD USA 21287 ed, Baltimore, MD 21287 USA Allelix Neurosci Inc, Cranbury, NJ 08512 USA Allelix Neurosci Inc Cranbury NJ USA 08512 ci Inc, Cranbury, NJ 08512 USA
Titolo Testata:
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
fascicolo: 3, volume: 44, anno: 2001,
pagine: 241 - 246
SICI:
0362-4803(20010315)44:3<241:ROALFS>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEGATIVE SYMPTOMS; SCHIZOPHRENIA; MODEL; EXPRESSION; CLONING;
Keywords:
glycine; GlyT1; glycine transporter; ALX-5407; carbon-11; positron emission tomography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Ravert, HT Johns Hopkins Med Inst, Dept Radiol, Div Nucl Med, 600 N Wolfe St, Baltimore, MD 21287 USA Johns Hopkins Med Inst 600 N Wolfe St BaltimoreMD USA 21287 SA
Citazione:
H.T. Ravert et al., "Radiosynthesis of a ligand for studying the glycine transporter: [C-11]ALX-5407", J LABEL C R, 44(3), 2001, pp. 241-246

Abstract

[C-11]ALX-5407, R-N[3-(4'-fluorophenyl)-3-(4'-phenylphenoxy)propyl] sarcosine, a chiral glycine transporter 1 antagonist, was labeled with [C-11]iodomethane by N-alkylation of methyl ester protected N-normethyl precursor, ALX-5536, and subsequent saponification of the methyl ester protecting group. The time for synthesis, purification, and formulation was 33 minutes with an average specific radioactivity of 3909 mCi/mu mol (EOS) and average decay corrected radiochemical yield of 8%.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 00:46:07