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Titolo:
Utility of the serum tumor markers: CYFRA 21.1, carcinoembryonic antigen (CEA), and squamous cell carcinoma antigen (SCC) in squamous cell lung cancer
Autore:
Tas, F; Aydiner, A; Topuz, E; Yasasever, V; Karadeniz, A; Saip, P;
Indirizzi:
Istanbul Univ, Inst Oncol, Dept Med Oncol, TR-34390 Istanbul, Turkey Istanbul Univ Istanbul Turkey TR-34390 Oncol, TR-34390 Istanbul, Turkey
Titolo Testata:
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
fascicolo: 4, volume: 19, anno: 2000,
pagine: 477 - 481
SICI:
0392-9078(200012)19:4<477:UOTSTM>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRONCHOGENIC CARCINOMA; HISTOLOGIC TYPES; EPITHELIA; DISEASES; FRAGMENT; ASSAY; TPA;
Keywords:
tumor marker; CEA; SCC; CYFRA 21.1; squamous lung cancer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Tas, F Istanbul Univ, Inst Oncol, Dept Med Oncol, TR-34390 Istanbul, Turkey Istanbul Univ Istanbul Turkey TR-34390 TR-34390 Istanbul, Turkey
Citazione:
F. Tas et al., "Utility of the serum tumor markers: CYFRA 21.1, carcinoembryonic antigen (CEA), and squamous cell carcinoma antigen (SCC) in squamous cell lung cancer", J EXP CL C, 19(4), 2000, pp. 477-481

Abstract

The aim of this study is to assess the clinical usefulness of serum assaysof carcinoembryonic antigen (CEA), squamous cell carcinoma antigen (SCC), and CYFRA 21.1 in the diagnosis of squamous cell lung cancer. Sixty patients with squamous cell, and twenty-four patients with nonsquamous cell histology of nonsmall cell lung cancer were enrolled in this study. Serum CEA, SCC, and CYFRA 21.1 levels were obtained by commercially available kits. Upper cutoff levels were 10 ng/ml, 3.5 ng/ml, and 3.5 ng/ml, respectively. In squamous cell lung cancer, percentages and 95% confidence interval (CI) of the patients with elevated levels were as follows: for CEA 23.3% (13-36), for SCC 20.0% (10-32), and for CYFRA 21.1 85.0% (73-93). The positivity rate of CYFRA 21.1 was more significant than CEA and SCC in both squamous and nonsquamous cell lung cancer. None of the markers were significant in differentiating squamous/nonsquamous histology. Only tumor marker CEA was significantly elevated in metastatic squamous cell lung cancer (p=0.004). A novel tumor marker CYFRA 21.1 can be used as a reliable tumor marker in diagnosingsquamous cell lung cancer. In addition, CEA has an important role in determining metastatic disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 00:46:59