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Titolo:
Expression of type II iodothyronine deiodinase in brain tumors
Autore:
Murakami, M; Araki, O; Morimura, T; Hosoi, Y; Mizuma, H; Yamada, M; Kurihara, H; Ishiuchi, S; Tamura, M; Sasaki, T; Mori, M;
Indirizzi:
Gunma Univ, Sch Med, Dept Internal Med 1, Maebashi, Gumma 3718511, Japan Gunma Univ Maebashi Gumma Japan 3718511 1, Maebashi, Gumma 3718511, Japan Gunma Univ, Sch Med, Dept Neurosurg, Maebashi, Gumma 3718511, Japan Gunma Univ Maebashi Gumma Japan 3718511 g, Maebashi, Gumma 3718511, Japan
Titolo Testata:
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
fascicolo: 11, volume: 85, anno: 2000,
pagine: 4403 - 4406
SICI:
0021-972X(200011)85:11<4403:EOTIID>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; RAT ASTROGLIAL CELLS; THYROID-HORMONE; 5'-DEIODINASE ACTIVITY; INDUCTION; CLONING; MODULATION; PITUITARY; TISSUES; ACID;
Tipo documento:
Editorial Material
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Murakami, M Gunma Univ, Sch Med, Dept Internal Med 1, Maebashi, Gumma 3718511, Japan Gunma Univ Maebashi Gumma Japan 3718511 Gumma 3718511, Japan
Citazione:
M. Murakami et al., "Expression of type II iodothyronine deiodinase in brain tumors", J CLIN END, 85(11), 2000, pp. 4403-4406

Abstract

Type II iodothyronine deiodinase (DII) messenger ribonucleic acid (mRNA) and its activity have been demonstrated in human normal brain. Although DII activity has been demonstrated in brain tumors, expression of DII mRNA has not been studied in these tumors. To investigate the mechanisms involved inthe expression of DII activity in brain tumors, we studied DII mRNA and DII activity in astrocytoma (two cases), glioblastoma (three cases), and oligodendroglioma (one case). DII mRNA, the size of which was indistinguishablefrom that in control cerebral cortical tissue, was demonstrated in all of the brain tumors tested, although the intensity of the hybridization signalshowed wide variation among the tumors. DII activity was also detected in all tumors. DII mRNA and DII activity were highest in the tissue from oligodendroglioma. A significantly positive correlation was observed between DIImRNA and DII activity in these tumors (r = 0.94; P < 0.01), suggesting that DII expression in brain tumors is regulated at the pretranslational level. The present results demonstrate, for the first time, that DII mRNA as well as DII activity are expressed in brain tumors, and that DII mRNA is significantly correlated with DII activity in those tissues.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 23:57:11