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Titolo:
Cerebrospinal fluid corticotropin-releasing hormone in healthy humans: Effects of yohimbine and naloxone
Autore:
Vythilingam, M; Anderson, GM; Owens, MJ; Halaszynski, TM; Bremner, JD; Carpenter, LL; Heninger, GR; Nemeroff, CB; Charney, DS;
Indirizzi:
Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06519 USA Yale Univ New Haven CT USA 06519 , Dept Psychiat, New Haven, CT 06519 USA Yale Univ, Sch Med, Dept Child Psychiat, New Haven, CT 06519 USA Yale Univ New Haven CT USA 06519 Child Psychiat, New Haven, CT 06519 USA Yale Univ, Sch Med, Dept Anesthesiol, New Haven, CT 06519 USA Yale Univ New Haven CT USA 06519 ept Anesthesiol, New Haven, CT 06519 USA Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 ychiat & Behav Sci, Atlanta, GA 30322 USA
Titolo Testata:
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
fascicolo: 11, volume: 85, anno: 2000,
pagine: 4138 - 4145
SICI:
0021-972X(200011)85:11<4138:CFCHIH>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTTRAUMATIC-STRESS-DISORDER; FACTOR-LIKE IMMUNOREACTIVITY; LOCUS-COERULEUS; PARAVENTRICULAR NUCLEUS; CORTISOL SECRETION; ANXIETY DISORDERS; RAT HYPOTHALAMUS; NOREPINEPHRINE; VASOPRESSIN; DEPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Vythilingam, M NIMH, Mood & Anxiety Disorders Res Program, 9000 Rockville Pike,Bldg 10,Room 4N222, Bethesda, MD 20892 USA NIMH 9000 Rockville Pike,Bldg 10,Room 4N222 Bethesda MD USA 20892
Citazione:
M. Vythilingam et al., "Cerebrospinal fluid corticotropin-releasing hormone in healthy humans: Effects of yohimbine and naloxone", J CLIN END, 85(11), 2000, pp. 4138-4145

Abstract

CRH neurons projecting from the paraventricular nucleus (PVN) of the hypothalamus to the median eminence control hypothalamic-pituitary-adrenal (HPA)axis activity. However, CRH neurons outside the PVN as well as PVN neuronsprojecting to sites other than the median eminence also contribute to the stress response and may play a role in mood and anxiety disorders. We have attempted to investigate possible noradrenergic and opioid regulation of these non-HPA CRH neurons. We hypothesized that yohimbine (an alpha (2)-adrenergic antagonist) would have stimulatory action on non-HPA CRH neurons, whereas naloxone (a mu -opioid receptor antagonist) would not have this effect. Adult normal volunteers received iv yohimbine (n = 5; 0.4 mug/kg), naloxone (n = 4; 125 mug/kg), or placebo (n = 3; 0.9% saline). Cerebrospinal fluid (CSF) was collected continuously, and concentrations of CSF CRH, CSF norepinephrine (NE), and plasma cortisol were measured. Administration of either yohimbine or naloxone caused significant increases in plasma cortisol concentrations over time. Although yohimbine robustly increased CSF NE levels and appeared to increase CSF CRH levels, these effects were not seen after naloxone or placebo administration. Intraindividual correlations were not observed between the measured concentrations of plasma cortisol and CSF CRH for any of the subjects. The results support the idea that CSF CRH concentrations reflect the activity of non-HPA CRH neurons. Although both yohimbineand naloxone stimulated the HPA axis, only yohimbine appeared to have stimulatory effects on central NE and non-HPA CRH.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:32:05