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Titolo:
Effects of long-term hormone therapy on cholinergic synaptic concentrations in healthy postmenopausal women
Autore:
Smith, YR; Minoshima, S; Kuhl, DE; Zubieta, JK;
Indirizzi:
Univ Michigan, Dept Obstet & Gynecol, Div Reprod Endocrinol, Ann Arbor, MI48109 USA Univ Michigan Ann Arbor MI USA 48109 d Endocrinol, Ann Arbor, MI48109 USA Univ Michigan, Dept Radiol, Div Nucl Med, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 iv Nucl Med, Ann Arbor, MI 48109 USA Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 pt Psychiat, Ann Arbor, MI 48109 USA Univ Michigan, Mental Hlth Res Inst, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 th Res Inst, Ann Arbor, MI 48109 USA
Titolo Testata:
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
fascicolo: 2, volume: 86, anno: 2001,
pagine: 679 - 684
SICI:
0021-972X(200102)86:2<679:EOLHTO>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
ESTROGEN-REPLACEMENT THERAPY; ACETYLTRANSFERASE MESSENGER-RNA; ALZHEIMERS-DISEASE; OLDER WOMEN; DIFFERENT REGIONS; BASAL FOREBRAIN; RELATIVE LEVELS; BRAIN; RISK; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Smith, YR Univ Michigan, Womens Hosp, Dept Obstet & Gynecol, Room L4224,1500 E Med Ctr Dr, Ann Arbor, MI 48109 USA Univ Michigan Room L4224,1500 E Med Ctr Dr Ann Arbor MI USA 48109
Citazione:
Y.R. Smith et al., "Effects of long-term hormone therapy on cholinergic synaptic concentrations in healthy postmenopausal women", J CLIN END, 86(2), 2001, pp. 679-684

Abstract

Experimental evidence suggests that gonadal steroids regulate brain neurochemical systems associated with cognitive function, such as the cholinergicsystem. This study examines the effect of long-term postmenopausal hormonetherapy on the brain concentrations of cholinergic synaptic terminals in women using single photon emission computed tomography and the radiotracer [I-123]iodobenzovesamicol ([I-123]IBVM). [I-123]IBVM labels the vesicular acetylcholine transporter (VAChT) located in the presynaptic terminals of these neurons. Sixteen healthy women treated with hormone therapy since the menopause and 12 women not treated with hormones were studied. There were no significant differences in regional IBVM binding indexes between the 2 groups. The length of hormone replacement therapy correlated positively with VAChT binding indexes in multiple cortical areas (P < 0.05): frontal cortex (Spearman rank correlation: <rho> = 0.79), parietal cortex (rho = 0.62), temporal cortex (rho = 0.80), anterior cingulate (rho = 0.71), and posterior cingulate (rho = 0.63), but not in the basal ganglia (rho = 0.35; P = 0.2). An earlier onset of menopause in hormone-treated women was associated with higher VAChT indexes in the anterior cingulate (rho = -0.56; P = 0.02) and posterior cingulate (rho = -0.63; P = 0.01). The opposite was found in the posterior cingulate of women not treated with hormones (rho = 0.58; P = 0.04). Women treated with estrogen alone also showed higher VAChT indexes thanwomen treated with estrogen and progestin in the posterior cingulate cortex (by Mann-Whitney U test: z = 2.42; P = 0.015). Although an overall effectof postmenopausal hormone therapy was not found, associations between an index of cortical cholinergic terminal concentrations and the length of hormonal replacement suggest that hormone therapy may influence the survival orplasticity of these cells in postmenopausal women. The data also suggest possible differential effects of estrogen and estrogen with progestin treatments in brain areas critical for cognitive processing.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 11:17:19