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Titolo:
Resolution of isomers of sorbitolparaben esters by chromatographic and electrophoretic techniques
Autore:
Blanco, M; Coello, J; Iturriaga, H; Maspoch, S; Romero, MA;
Indirizzi:
Univ Autonoma Barcelona, Fac Ciencies, Dept Quim, Unit Quim Analit, E-08193 Bellaterra, Spain Univ Autonoma Barcelona Bellaterra Spain E-08193 08193 Bellaterra, Spain
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY B
fascicolo: 1, volume: 752, anno: 2001,
pagine: 99 - 105
SICI:
1387-2273(20010305)752:1<99:ROIOSE>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAPILLARY ZONE ELECTROPHORESIS; SEPARATION; PARABENS; BEHAVIOR; POLYOLS; ACID;
Keywords:
sorbitol; methylparaben;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Blanco, M Univ Autonoma Barcelona, Fac Ciencies, Dept Quim, Unit Quim Analit, E-08193 Bellaterra, Spain Univ Autonoma Barcelona Bellaterra Spain E-08193 aterra, Spain
Citazione:
M. Blanco et al., "Resolution of isomers of sorbitolparaben esters by chromatographic and electrophoretic techniques", J CHROMAT B, 752(1), 2001, pp. 99-105

Abstract

Pharmaceutical preparations usually contain preservatives and sweeteners. When parabens are used as preservatives and a polyol as a sweetener, a transesterification reaction may happen, yielding the transester polyol-paraben. The products formed in the transesterification reaction of methylparaben and sorbitol were analyzed by micellar electrokinetic chromatography and byHPLC. Up to six positional isomers of sorbitolparaben (SPB) can be produced. However, only three peaks were found by HPLC. The higher efficiency and resolution power of MEKC allowed one to resolve five peaks. Results were compared with those obtained by capillary zone electrophoresis in berate buffer, where the separation of isomers occurred in a different way, because ofa complexation between SPB and berate. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 09:52:47