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Titolo:
Separation of olanzapine, carbamazepine and their main metabolites by capillary electrophoresis with pseudo-stationary phases
Autore:
Izzo, G; Raggi, MA; Maichel, B; Kenndler, E;
Indirizzi:
Univ Bologna, Dept Pharmaceut Sci, I-40126 Bologna, Italy Univ Bologna Bologna Italy I-40126 harmaceut Sci, I-40126 Bologna, Italy Univ Vienna, Inst Analyt Chem, A-1090 Vienna, Austria Univ Vienna ViennaAustria A-1090 st Analyt Chem, A-1090 Vienna, Austria
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY B
fascicolo: 1, volume: 752, anno: 2001,
pagine: 47 - 53
SICI:
1387-2273(20010305)752:1<47:SOOCAT>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; PHARMACOLOGICAL PROPERTIES; ELECTROCHEMICAL DETECTION; SCHIZOPHRENIA; DRUGS; SERUM;
Keywords:
olanzepine; carbamazepine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Kenndler, E Univ Bologna, Dept Pharmaceut Sci, I-40126 Bologna, Italy UnivBologna Bologna Italy I-40126 i, I-40126 Bologna, Italy
Citazione:
G. Izzo et al., "Separation of olanzapine, carbamazepine and their main metabolites by capillary electrophoresis with pseudo-stationary phases", J CHROMAT B, 752(1), 2001, pp. 47-53

Abstract

Conditions were worked out for the separation of carbamazepine, olanzapine, and their main metabolites carbamazepine 10,11-epoxide, 10-hydroxycarbamazepine, and desmethylolanzapine. The separation was based on electrokinetically driven methods in the capillary format. The main difficulty in separating these compounds is related to their different chemical classes. Whereasthe carbamazepine members are amides, and are electrically neutral, the olanzapine members have aliphatic amino groups and are thus cationic under most experimental conditions. Different additives were applied as pseudo-stationary phases to implement selectivity. Poly(diallyldimethylammonium), PDADMA, is a polycationic replaceable and soluble polymer, that interacts mainly according to the polarisability of the analyte molecules. The MEKC principle was applied with the common SDS as micelle former. In both systems, only partial resolution of the analytes was obtained. The most favorable system consisted of a charged, oligomeric additive: full separation of all analytes within 4 min was achieved with heptakis-6-sulfato-beta -cyclodextrin (7mM) in 30 mM berate buffer, pH 8.5. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:38:11