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Titolo:
Altered self-reactive antibody repertoires are a general feature of patients with myelodysplastic syndrome
Autore:
Stahl, D; Egerer, G; Goldschmidt, H; Sibrowski, W; Kazatchkine, MD; Kaveri, SV;
Indirizzi:
Univ Munster, Inst Transfus Med, D-48149 Munster, Germany Univ Munster Munster Germany D-48149 nsfus Med, D-48149 Munster, Germany INSERM, U430, F-75014 Paris, France INSERM Paris France F-75014INSERM, U430, F-75014 Paris, France Univ Paris 06, Hop Broussais, F-75014 Paris, France Univ Paris 06 Paris France F-75014 Hop Broussais, F-75014 Paris, France Univ Klinikum Heldelberg, Med Klin & Poliklin 5, D-69115 Heidelberg, Germany Univ Klinikum Heldelberg Heidelberg Germany D-69115 Heidelberg, Germany
Titolo Testata:
JOURNAL OF AUTOIMMUNITY
fascicolo: 1, volume: 16, anno: 2001,
pagine: 77 - 86
SICI:
0896-8411(200102)16:1<77:ASARAA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUTOIMMUNE HEMOLYTIC-ANEMIA; HUMAN NEUROBLASTOMA-CELLS; NORMAL HUMAN SERUM; IMMUNOLOGICAL ABNORMALITIES; AUTOREACTIVE REPERTOIRES; NATURAL AUTOANTIBODIES; HEALTHY-INDIVIDUALS; MOLECULAR-BIOLOGY; INDUCE APOPTOSIS; STEM-CELL;
Keywords:
antibody repertoires; haematopoiesis; myelodysplastic syndrome; quantitative immunoblotting; self reactivity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Stahl, D Univ Munster, Inst Transfus Med, Domagkstr 11, D-48149 Munster, Germany Univ Munster Domagkstr 11 Munster Germany D-48149 nster, Germany
Citazione:
D. Stahl et al., "Altered self-reactive antibody repertoires are a general feature of patients with myelodysplastic syndrome", J AUTOIMMUN, 16(1), 2001, pp. 77-86

Abstract

Myelodysplastic syndrome (MDS) is characterized by an acquired clonal disorder of haematopoietic progenitor cells that results in inhibition of normal haematopoiesis and contributes to the development of haematological malignancies. Autoimmune syndromes may occur in MDS, but they are not a major clinical feature of the disease. Ln the present study, we have analysed the global antibody repertoires of IgM and IgG in plasma of 10 patients with MDStoward self- and non-self-antigens by quantitative immunoblotting. Myelodysplastic syndrome patients included in this study did not exhibit autoimmune symptoms nor secondary haematological neoplastic disease. Data were compared by means of multiparametric statistical analysis. We demonstrate that the antibody repertoires of self-reactive IgM and IgG of patients with MDS exhibit significantly altered patterns of reactivity, as compared to those of healthy individuals. In contrast, reactivity patterns of IgM in plasma ofpatients and of healthy controls toward non-self-antigens were similar, whereas reactivity patterns of IgG of patients and healthy subjects toward non-self-antigens were discriminated by multiparametric statistical analysis. These observations indicate that a broad disturbance of self-recognition mechanisms is a general feature of patients with MDS. A failure in the regulation of self-reactivity may contribute to the pathogenesis of MDS. (C) 2001 Academic Press.

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Documento generato il 03/04/20 alle ore 13:12:54