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Titolo:
Characteristics of inflammatory cells in spontaneous autoimmune thyroiditis of NOD.H-2h4 mice
Autore:
Yu, SG; Medling, B; Yagita, H; Braley-Mullen, H;
Indirizzi:
Univ Missouri, Dept Internal Med, Columbia, MO USA Univ Missouri ColumbiaMO USA souri, Dept Internal Med, Columbia, MO USA Dept Vet Affairs Med Ctr, Res Serv, Columbia, MO 65212 USA Dept Vet Affairs Med Ctr Columbia MO USA 65212 rv, Columbia, MO 65212 USA Juntendo Univ, Sch Med, Dept Immunol, Tokyo 1138421, Japan Juntendo Univ Tokyo Japan 1138421 ed, Dept Immunol, Tokyo 1138421, Japan Univ Missouri, Dept Mol Microbiol & Immunol, Columbia, MO 65212 USA Univ Missouri Columbia MO USA 65212 iol & Immunol, Columbia, MO 65212 USA
Titolo Testata:
JOURNAL OF AUTOIMMUNITY
fascicolo: 1, volume: 16, anno: 2001,
pagine: 37 - 46
SICI:
0896-8411(200102)16:1<37:COICIS>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; CD4 T-CELLS; OX40 LIGAND; IN-VIVO; B-CELLS; MULTIPLE-SCLEROSIS; DENDRITIC CELLS; OBESE STRAIN; ANIMAL-MODEL; NOD MICE;
Keywords:
activation; autoimmunity; germinal centre; inflammatory cell; thyroiditis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Braley-Mullen, H Univ Missouri, Dept Med, Div Immunol, M450 Med Sci, Columbia, MO 65212 USA Univ Missouri M450 Med Sci Columbia MO USA 65212 5212 USA
Citazione:
S.G. Yu et al., "Characteristics of inflammatory cells in spontaneous autoimmune thyroiditis of NOD.H-2h4 mice", J AUTOIMMUN, 16(1), 2001, pp. 37-46

Abstract

Thyroid lesions develop in most NOD.H-2h4 mice 6 weeks after they are given 0.05% NaI in drinking water. B cells are required for spontaneous autoimmune thyroiditis (SAT) development, and anti-thyroglobulin autoantibody levels correlate with SAT severity. Immunohistochemical staining of thyroids obtained 2-10 weeks after administration of NaI water suggested that CD4+ T cells initially infiltrated the thyroid, followed by CD8+ T cells and B cells. Intrathyroidal CD4+ T cells are more numerous than CD8+ T cells. CD4+ T cells and B cells form aggregates in the thyroid, while CD8+ T cells are scattered throughout the thyroid. Intrathyroidal germinal centre-like structures could be observed in thyroid lesions with 2-3+ SAT and intrathyroidal Bcells co-expressed OX40L. By RT-PCR, intrathyroidal expression of OX40L, OX40, CD40L, IL-2R CTLA-4 and Ig beta mRNA correlated closely with the SAT severity score. These molecules were not expressed in normal thyroids. In the spleen, OX40L-positive cells were detected at 2 weeks and increased 4-6 weeks after NaI water. OX40, OX40L, CD40L, IL-2R and B7-1 as well. as IFN-gamma and IL-4 mRNA were minimally expressed in normal spleens, usually beganto be expressed at 2 weeks and increased to maximal level 4-8 weeks after NaI water. These results suggest that in NOD.H-2h4 mice, the OX40L, OX40, CD40L and B7 molecules, which increase in the spleen and thyroid of these mice after receiving NaI water, may play a role in SAT development, implying that one or more of these molecules might be good targets for the prevention or treatment of SAT. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 14:13:33