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Titolo:
Short-term exercise training increases ACh-induced relaxation and eNOS protein in porcine pulmonary arteries
Autore:
Johnson, LR; Rush, JWE; Turk, JR; Price, EM; Laughlin, MH;
Indirizzi:
Univ Missouri, Dept Vet Biomed Sci, Columbia, MO 65211 USA Univ Missouri Columbia MO USA 65211 et Biomed Sci, Columbia, MO 65211 USA Univ Missouri, Vet Diagnost Lab, Columbia, MO 65211 USA Univ Missouri Columbia MO USA 65211 Diagnost Lab, Columbia, MO 65211 USA Univ Missouri, Dalton Cardiovasc Res Ctr, Columbia, MO 65211 USA Univ Missouri Columbia MO USA 65211 ovasc Res Ctr, Columbia, MO 65211 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 3, volume: 90, anno: 2001,
pagine: 1102 - 1110
SICI:
8750-7587(200103)90:3<1102:SETIAR>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIUM-MEDIATED DILATION; CORONARY ARTERIOLES; SKELETAL-MUSCLE; BLOOD-FLOW; EXPRESSION; RESPONSES; DISEASE; REHABILITATION; SWINE; PIGS;
Keywords:
pulmonary circulation; nitric oxide synthase; superoxide dismutase; acetylcholine; endothelium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Johnson, LR Univ Calif Davis, Sch Vet Med, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 Med, Davis, CA 95616 USA
Citazione:
L.R. Johnson et al., "Short-term exercise training increases ACh-induced relaxation and eNOS protein in porcine pulmonary arteries", J APP PHYSL, 90(3), 2001, pp. 1102-1110

Abstract

Short-term exercise training increases ACh-induced relaxation and eNOS protein in porcine pulmonary arteries. J Appl Physiol 90: 1102-1110, 2001.-We tested the hypothesis that short-term; exercise (STEx) training and the associated increase in pulmonary blood flow during bouts of exercise cause enhanced endothelium-dependent vasorelaxation in porcine pulmonary arteries and increased expression of endothelial cell nitric oxide synthase (eNOS) andsuperoxide dismutase-1 (SOD-1) protein. Mature, female Yucatan miniature swine exercised 1 h twice daily on a motorized treadmill for 1 wk (STEx group, n = 7); control pigs (Sed, n = 6) were kept in pens. Pulmonary arteries were isolated from the left caudal lung lobe, and vasomotor responses were determined in vitro. Arterial tissue from the distal portion of this pulmonary artery was processed for immunoblot analysis. Maximal endothelium-dependent (ACh-stimulated) relaxation was greater in STEx (71 +/- 5%) than in Sed (44 +/- 6%) arteries (P < 0.05), and endothelium-independent (sodium nitroprusside-mediated) responses did not differ. Sensitivity to ACh was not altered by STEx training. Immunoblot analysis indicated a 3.9-fold increase in eNOS protein in pulmonary artery tissue from STEx pigs (P < 0.05) with nochange in SOD-1 or glyceraldehyde-3-phosphate dehydrogenase protein levels. We conclude that STEx training enhances ACh-stimulated vasorelaxation in pulmonary arterial tissue and that this adaptation is associated with increased expression of eNOS protein.

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Documento generato il 04/04/20 alle ore 01:42:06