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Titolo:
Catecholamines increase lung edema clearance in rats with increased left atrial pressure
Autore:
Azzam, ZS; Saldias, FJ; Comellas, A; Ridge, KM; Rutschman, DH; Sznajder, JI;
Indirizzi:
Northwestern Univ, Div Pulm & Crit Care Med, Chicago, IL 60611 USA Northwestern Univ Chicago IL USA 60611 it Care Med, Chicago, IL 60611 USA NE Illinois Univ, Dept Math, Chicago, IL 60625 USA NE Illinois Univ Chicago IL USA 60625 v, Dept Math, Chicago, IL 60625 USA Technion Israel Inst Technol, Dept Med, IL-31096 Haifa, Israel Technion Israel Inst Technol Haifa Israel IL-31096 L-31096 Haifa, Israel Catholic Univ Chile, Fac Med, Dept Enfermedades Resp, Santiago, Chile Catholic Univ Chile Santiago Chile t Enfermedades Resp, Santiago, Chile
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 3, volume: 90, anno: 2001,
pagine: 1088 - 1094
SICI:
8750-7587(200103)90:3<1088:CILECI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONGESTIVE-HEART-FAILURE; HYDROSTATIC PULMONARY-EDEMA; LIQUID CLEARANCE; SODIUM-TRANSPORT; FLUID TRANSPORT; MECHANISMS; RABBIT; SHEEP; HYPERTENSION; STIMULATION;
Keywords:
active sodium transport; cytoskeleton;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Sznajder, JI Northwestern Univ, Div Pulm & Crit Care Med, Tarry 14-707,300E Super St, Chicago, IL 60611 USA Northwestern Univ Tarry 14-707,300 E Super St Chicago IL USA 60611
Citazione:
Z.S. Azzam et al., "Catecholamines increase lung edema clearance in rats with increased left atrial pressure", J APP PHYSL, 90(3), 2001, pp. 1088-1094

Abstract

Catecholamines increase lung edema clearance in rats with increased left atrial pressure. J Appl Physiol 90: 1088-1094, 2001.-During hydrostatic pulmonary edema, active Na+ transport and alveolar fluid reabsorption are decreased. Dopamine (DA) and isoproterenol (ISO) have been shown to increase active Na+ transport in rat lungs by upregulating Na+-K+-ATPase in the alveolar epithelium. We studied the effects of DA and ISO in isolated rat lungs with increased left atrial pressure (Pla = 15 cmH(2)O) compared with control rats with normal Pla (Pla = 0). Alveolar fluid reabsorption decreased from control value of 0.51 +/- 0.02 to 0.27 +/- 0.02 ml/h when Pla was increasedto 15 cmH(2)O (P < 0.001). DA and ISO increased the alveolar fluid reabsorption back to control levels. Treatment with the D-1 antagonist SCH-23390 inhibited the stimulatory effects of DA (0.30 +/- 0.02 ml/h), whereas fenoldopam, a specific D-1- receptor agonist, increased alveolar fluid reabsorption in rats exposed to Pla of 15 cmH(2)O (0.47 +/- 0.04 ml/h). Propranolol, a <beta>-adrenergic-receptor antagonist, blocked the stimulatory effects ofISO; however, it did not affect alveolar fluid reabsorption in control or DA-treated rats. Amiloride (a Na+ channel blocker) and ouabain (a Na+-K+-ATPase inhibitor), either alone or together, inhibited the stimulatory effects of DA. Colchicine, which disrupts the cellular microtubular transport of ion-transporting proteins to the plasma membrane, inhibited the stimulatoryeffects of DA, whereas the isomer beta -lumicolchicine did not block the stimulatory effects of DA. These data suggest that DA and ISO increase alveolar fluid reabsorption in a model of increased Pla by regulating active Natransport in rat alveolar epithelium. The effects of DA and ISO are mediated by the activation of dopaminergic D-1 receptors and the beta -adrenergicreceptors, respectively.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 19:42:22