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Titolo:
Depression of ventilatory responses after daily, cyclic hypercapnic hypoxia in piglets
Autore:
Waters, KA; Tinworth, KD;
Indirizzi:
Univ Sydney, David Read Lab, Dept Med, Sydney, NSW 2006, Australia Univ Sydney Sydney NSW Australia 2006 pt Med, Sydney, NSW 2006, Australia Univ Sydney, Dept Paediat & Child Hlth, Sydney, NSW 2006, Australia Univ Sydney Sydney NSW Australia 2006 d Hlth, Sydney, NSW 2006, Australia
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 3, volume: 90, anno: 2001,
pagine: 1065 - 1073
SICI:
8750-7587(200103)90:3<1065:DOVRAD>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSTRUCTIVE SLEEP-APNEA; SUDDEN-INFANT-DEATH; POSTNATAL-DEVELOPMENT; RESPIRATORY RESPONSES; REPETITIVE HYPOXIA; CHALLENGES; CHILDREN; AROUSAL; GOATS; RATS;
Keywords:
hypercapnia; repetitive; development; ventilatory response;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Waters, KA Univ Sydney, David Read Lab, Dept Med, Rm 206,Blackburn Bldg,DO6, Sydney, NSW 2006, Australia Univ Sydney Rm 206,Blackburn Bldg,DO6 SydneyNSW Australia 2006
Citazione:
K.A. Waters e K.D. Tinworth, "Depression of ventilatory responses after daily, cyclic hypercapnic hypoxia in piglets", J APP PHYSL, 90(3), 2001, pp. 1065-1073

Abstract

Depression of ventilatory responses after daily, cyclic hypercapnic hypoxia in piglets. J Appl Physiol 90: 1065-1073, 2001.-Ventilatory responses (VRs) were measured via a sealed face mask and pneumotachograph in 30 unsedated, mixed-breed miniature piglets at 12.6 +/- 2.3 days of age (day 1) and then repeated after seven daily 24-min exposures to 10% O-2-6% CO2 [hypercapnic hypoxia (HH)]. Arterial blood was sampled at baseline, after 10 min of exposure, and after 10 min of recovery. VRs included hypoxia (10% O-2 in N-2), hypercapnia (6% CO2 in air), and HH (10% O-2-6% CO2-balance N-2). Treatment groups (n = 10 each) were exposed to 24 min of HH from day 2 to 8 as sustained HH (24 min of HH and then 24 min of air) or cyclic HH (4 min of HH alternating with 4 min of air). Day 1 and 9 data were compared in treatmentand control groups. After cyclic HH, respiratory responses to CO2 were reduced during hypercapnia and during HH (P < 0.001 vs. control for minute ventilation in both). In both treatment groups, time to peak minute ventilation was delayed in hypoxia (P = 0.02, ANOVA), and response amplitude was increased (P < 0.001 and P = 0.003, sustained and cyclic HH, respectively, vs, control). Respiratory pattern was also altered during the VRs and among treatment groups. Stimulus presentation characteristics exert effects on VRs that are independent of those elicited by daily HH.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 12:14:57