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Titolo:
Muscimol dialysis in the rostral ventral medulla reduced the CO2 response in awake and sleeping piglets
Autore:
Curran, AK; Darnall, RA; Filiano, JJ; Li, AH; Nattie, EE;
Indirizzi:
Dartmouth Coll, Hitchcock Med Ctr, Dept Physiol, Lebanon, NH 03756 USA Dartmouth Coll Lebanon NH USA 03756 , Dept Physiol, Lebanon, NH 03756 USA Dartmouth Med Sch, Dept Physiol, Lebanon, NH 03756 USA Dartmouth Med Sch Lebanon NH USA 03756 ept Physiol, Lebanon, NH 03756 USA Dartmouth Coll, Hitchcock Med Ctr, Dept Neurol, Lebanon, NH 03756 USA Dartmouth Coll Lebanon NH USA 03756 r, Dept Neurol, Lebanon, NH 03756 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 3, volume: 90, anno: 2001,
pagine: 971 - 980
SICI:
8750-7587(200103)90:3<971:MDITRV>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFANT-DEATH-SYNDROME; RESPIRATORY RHYTHM GENERATOR; C-FOS EXPRESSION; RETROTRAPEZOID NUCLEUS; RECEPTOR-BINDING; ARCUATE NUCLEUS; BRAIN-STEM; VENTILATORY RESPONSE; NEWBORN RAT; LESIONS;
Keywords:
central chemoreceptors; sudden infant death; parapyramidal; raphe; retrotrapezoid nucleus; nucleus paragigantocellularis lateralis; arcuate nucleus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Curran, AK Dartmouth Coll, Hitchcock Med Ctr, Dept Physiol, 1 Med Ctr Dr, Lebanon, NH03756 USA Dartmouth Coll 1 Med Ctr Dr Lebanon NH USA 03756 n, NH03756 USA
Citazione:
A.K. Curran et al., "Muscimol dialysis in the rostral ventral medulla reduced the CO2 response in awake and sleeping piglets", J APP PHYSL, 90(3), 2001, pp. 971-980

Abstract

Some victims of sudden infant death syndrome have arcuate nucleus abnormalities. The arcuate nucleus may be homologous with ventral medullary structures in the cat known to be involved in the control of breathing and the response to systemic hypercapnia. We refer to putative arcuate homologues in the piglet collectively as the rostral ventral medulla (RVM). We inhibited the RVM in awake and sleeping, chronically instrumented piglets by microdialysis of the GABA, receptor agonist muscimol. Muscimol dialysis (10 and 40 mM) had no effect on eupnea but caused a significant reduction in the response to hypercapnia during both wakefulness (34.8 +/- 8.7 and 30.7 +/- 10.1%,respectively) and sleep (36.7 +/- 6.7 and 49.5 +/- 8.9%, respectively). The effect of muscimol on the CO2 response was entirely via a reduction in tidal volume and appeared to be greater during non-rapid-eye-movement sleep. We conclude that the piglet RVM contains neurons of importance in the response to systemic CO2 during both wakefulness and nonrapid-eye-movement sleep. We hypothesize that dysfunction of homologous regions in the human infantcould lead to impaired ability to respond to hypercapnia, particularly during sleep, which could potentially be involved in the pathogenesis of sudden infant death syndrome.

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Documento generato il 23/01/20 alle ore 03:58:51