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Titolo:
L-Arginine enhances aerobic exercise capacity in association with augmented nitric oxide production
Autore:
Maxwell, AJ; Ho, HV; Le, CQ; Lin, PS; Bernstein, D; Cooke, JP;
Indirizzi:
Stanford Univ, Sect Vasc Med, Div Cardiovasc Med, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 ardiovasc Med, Stanford, CA 94305 USA Stanford Univ, Sect Vasc Med, Div Pediat Cardiol, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 ediat Cardiol, Stanford, CA 94305 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 3, volume: 90, anno: 2001,
pagine: 933 - 938
SICI:
8750-7587(200103)90:3<933:LEAECI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORAL L-ARGININE; CHRONIC HEART-FAILURE; INDUCED VASODILATION; SKELETAL-MUSCLE; RELAXING FACTOR; ACTIVE HYPEREMIA; BLOOD-FLOW; HUMANS; SUPPLEMENTATION; RESPIRATION;
Keywords:
oxygen uptake; vascular reactivity; hypercholesterolemia; apolipoprotein E knockout; D-arginine; endothelium-derived relaxing factor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Maxwell, AJ 1404 Old Cty Rd, Belmont, MA USA 1404 Old Cty Rd Belmont MA USA 4 Old Cty Rd, Belmont, MA USA
Citazione:
A.J. Maxwell et al., "L-Arginine enhances aerobic exercise capacity in association with augmented nitric oxide production", J APP PHYSL, 90(3), 2001, pp. 933-938

Abstract

We tested whether supplementation with L-arginine can augment aerobic capacity, particularly in conditions where endothelium-derived nitric oxide (EDNO) activity is reduced. Eight-week-old wild-type (E+) and apolipoprotein E-deficient mice (E-) were divided into six groups; two groups (LE+ and LE-)were given L-arginine (6% in drinking water), two were given D-arginine (DE+ and DE-), and two control groups (NE+ and NE-) received no arginine supplementation. At 12-16 wk of age, the mice were treadmill tested, and urine was collected after exercise for determination of EDNO production. NE- micedemonstrated a reduced aerobic capacity compared with NE+ controls [maximal oxygen uptake ((V) over dot O-2 max) of NE- = 110 +/- 2 (SE) vs. NE+ = 122 +/- 3 ml O-2.min(-1).g(-1), P < 0.001]. This decline in aerobic capacity was associated with a diminished postexercise urinary nitrate excretion. Mice given L-arginine demonstrated an increase in postexercise urinary nitrate excretion and aerobic capacity in both groups ((V) over dot O-2 max of LE- = 120 +/- 1 mi O-2.min(-1).kg(-1) P < 0.05 vs. NE-; (V) over dot O-2 max of LE+ = 133 +/- 4 ml O-2.min(-1).kg(-1), P < 0.01 vs. NE+). Mice administered D-arginine demonstrated an intermediate increase in aerobic capacity inboth groups. We conclude that administration of L-arginine: restores exercise-induced EDNO synthesis and normalizes aerobic capacity in hypercholesterolemic mice. In normal mice, L-arginine enhances exercise-induced EDNO synthesis and aerobic capacity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/21 alle ore 03:30:09