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Titolo:
Exogenous testosterone treatment decreases diaphragm neuromuscular transmission failure in male rats
Autore:
Blanco, CE; Zhan, WZ; Fang, YH; Sieck, GC;
Indirizzi:
Univ So Calif, Dept Biokinesiol & Phys Therapy, Los Angeles, CA 90033 USA Univ So Calif Los Angeles CA USA 90033 Therapy, Los Angeles, CA 90033 USA Mayo Clin & Mayo Fdn, Dept Anesthesiol, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 siol, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn, Dept Physiol & Biophys, Rochester, MN 55905 USA MayoClin & Mayo Fdn Rochester MN USA 55905 phys, Rochester, MN 55905 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 3, volume: 90, anno: 2001,
pagine: 850 - 856
SICI:
8750-7587(200103)90:3<850:ETTDDN>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
VESICULAR ACETYLCHOLINE TRANSPORTER; SKELETAL-MUSCLE FIBERS; LEVATOR ANI MUSCLE; CHOLINE-ACETYLTRANSFERASE; ANABOLIC-STEROIDS; SPINAL-CORD; DEHYDROGENASE ACTIVITY; ANDROGEN RECEPTOR; STRIATED-MUSCLE; LIMB MUSCLES;
Keywords:
fatigue; contractile properties; anabolic-androgenic steroids;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Blanco, CE Univ So Calif, Dept Biokinesiol & Phys Therapy, 1540 E Alcazar St,CHP 155,Los Angeles, CA 90033 USA Univ So Calif 1540 E Alcazar St,CHP 155 Los Angeles CA USA 90033
Citazione:
C.E. Blanco et al., "Exogenous testosterone treatment decreases diaphragm neuromuscular transmission failure in male rats", J APP PHYSL, 90(3), 2001, pp. 850-856

Abstract

The effect of chronic exogenous testosterone (T) treatment on neuromuscular transmission in the diaphragm (Dia) muscle of adult male rats Was determined. The contribution of neuromuscular transmission failure (NTF) to Dia fatigue was evaluated by superimposing intermittent direct muscle stimulationon repetitive nerve stimulation of isometric contraction in vitro. T treatment significantly reduced the contribution of NTF to Dia fatigue by similar to 20% (P < 0.001). Fiber type-specific effects on NTF Were determined bymeasuring Dia fiber glycogen levels subsequent to repetitive nerve or muscle stimulation. T treatment had no effect on glycogen depletion in Dia typeI and IIa fibers regardless of stimulation route. In the control group, type IIx fibers demonstrated significantly less glycogen depletion after nerve stimulation compared with direct muscle stimulation (P < 0.05), suggesting the presence of NTF. In contrast, T treatment increased glycogen depletion of type IIx fibers during nerve stimulation to levels similar to those after direct muscle stimulation. These data indicate that testosterone treatment substantially improves neuromuscular transmission in the Dia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 13:04:13