Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Treatment with endothelin-receptor antagonists increases NOS activity in hypercholesterolemia
Autore:
Taner, CB; Severson, SR; Best, PJM; Lerman, A; Miller, VM;
Indirizzi:
Mayo Clin & Mayo Fdn, Dept Surg, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 Surg, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn, Dept Internal Med, Div Cardiovasc Dis, Rochester, MN55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 c Dis, Rochester, MN55905 USA Mayo Clin & Mayo Fdn, Dept Internal Med, Dept Physiol & Biophys, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 phys, Rochester, MN 55905 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 3, volume: 90, anno: 2001,
pagine: 816 - 820
SICI:
8750-7587(200103)90:3<816:TWEAIN>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE; B RECEPTOR; VASCULAR TONE; IN-VITRO; AORTA; CELLS; PEPTIDE; RATS;
Keywords:
atherosclerosis; endothelial cells; endothelin-1; lipidemia; messenger ribonucleic acid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Miller, VM Mayo Clin & Mayo Fdn, Dept Surg, 200 1st St SW, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn 200 1st St SW Rochester MN USA 55905 5 USA
Citazione:
C.B. Taner et al., "Treatment with endothelin-receptor antagonists increases NOS activity in hypercholesterolemia", J APP PHYSL, 90(3), 2001, pp. 816-820

Abstract

In experimental hypercholesterolemia, endothelium-dependent relaxations decrease, as does endothelial immunoreactivity for nitric oxide (NO) synthase(NOS; eNOS) in coronary arteries. Systemic levels of NO also decrease withconcomitant elevations in systemic circulating levels of endothelin (ET)-1. Chronic treatment of hypercholesterolemic pigs with ET-receptor antagonists increases circulating NO and improves endothelium-dependent relaxations. Mechanisms causing these increases are not known. Therefore, experiments were designed to test the hypothesis that chronic administration of ET-receptor antagonists to hypercholesterolemic pigs increases NO production through increases in NOS activity. Female juvenile pigs were fed a 2% cholesterolatherogenic diet and were randomly allocated to receive no treatment (controls), a selective ETA-receptor antagonist (ABT-624), or a combined ETA + ETB-receptor antagonist (RO-48-5695) daily for 12 wk. After 12 wk, endothelial cells from thoracic aorta were prepared for measurement of eNOS mRNA or eNOS activity. Total cholesterol, low-density-lipoprotein cholesterol, and concentrations of ET-1 were significantly higher in all three groups at 12 wk compared with baseline levels. Circulating plasma-oxidized products of NO (NOx) increased with ET-receptor blockade. NOS mRNA was similar among groups. Total and Ca-dependent NOS: activity was significantly higher in aortic endothelial cells from the ETA + ETB-treated pigs compared with those treated with ETA antagonist alone. These results suggest that changes in systemic NOx after chronic inhibition of ETA + ETB receptors in hypercholesterolemia may result from posttranscriptional changes in NOS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/01/21 alle ore 22:47:30