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Titolo:
Fiber-type susceptibility to eccentric contraction-induced damage of hindlimb-unloaded rat AL muscles
Autore:
Vijayan, K; Thompson, JL; Norenberg, KM; Fitts, RH; Riley, DA;
Indirizzi:
Med Coll Wisconsin, Dept Cell Biol Neurobiol & Anat, Milwaukee, WI 53226 USA Med Coll Wisconsin Milwaukee WI USA 53226 & Anat, Milwaukee, WI 53226 USA Marquette Univ, Dept Biol, Milwaukee, WI 53233 USA Marquette Univ Milwaukee WI USA 53233 Dept Biol, Milwaukee, WI 53233 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 3, volume: 90, anno: 2001,
pagine: 770 - 776
SICI:
8750-7587(200103)90:3<770:FSTECD>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADDUCTOR LONGUS MUSCLES; HUMAN SOLEUS MUSCLE; SKELETAL-MUSCLE; INDUCED INJURY; MOTOR UNITS; SARCOMERE LESIONS; EXERCISE; HISTOCHEMISTRY; SPACEFLIGHT; MODEL;
Keywords:
skeletal muscle; missing A-band lesions; motor unit recruitment; hybrid fibers; reloading; adductor longus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Riley, DA Med Coll Wisconsin, Dept Cell Biol Neurobiol & Anat, 8701 Watertown Plank Rd, Milwaukee, WI 53226 USA Med Coll Wisconsin 8701 Watertown Plank Rd Milwaukee WI USA 53226
Citazione:
K. Vijayan et al., "Fiber-type susceptibility to eccentric contraction-induced damage of hindlimb-unloaded rat AL muscles", J APP PHYSL, 90(3), 2001, pp. 770-776

Abstract

Slow oxidative (SO) fibers,of the adductor longus (AL) were predominantly damaged during voluntary reloading of hindlimb unloaded (HU) rats and appeared explainable by preferential SO fiber recruitment. The present study assessed damage after eliminating the variable of voluntary recruitment by tetanically activating all fibers in situ through the motor nerve while applying eccentric (lengthening) or isometric contractions. Muscles were aldehydefixed and resin embedded, and semithin sections were cut. Sarcomere lesions were quantified in toluidine blue-stained sections. Fibers were typed in serial sections immunostained with antifast myosin and antitotal myosin (which highlights slow fibers). Both isometric and eccentric paradigms caused fatigue. Lesions occurred only in eccentrically contracted control and HU muscles. Fatigue did not cause lesions. HU increased damage because lesioned-fiber percentages within fiber types and lesion sizes were greater than control. Fast oxidative glycolytic (FOG) fibers were predominantly damaged. In no case did damaged SO fibers predominate. Thus, when FOG, SO, and hybridfibers are actively lengthened in chronically unloaded muscle, FOG fibers are intrinsically more susceptible to damage than SO fibers. Damaged hybrid-fiber proportions ranged between these extremes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 22:34:23