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Titolo:
IL-18 might reflect disease activity in mild and moderate asthma exacerbation
Autore:
Tanaka, H; Miyazaki, N; Oashi, K; Teramoto, S; Shiratori, M; Hashimoto, M; Ohmichi, M; Abe, S;
Indirizzi:
Sapporo Med Univ, Sch Med, Dept Internal Med 3, Chuo Ku, Sapporo, Hokkaido0608543, Japan Sapporo Med Univ Sapporo Hokkaido Japan 0608543 o, Hokkaido0608543, Japan Hokkaido Railway, Sapporo Hosp, Sapporo, Hokkaido, Japan Hokkaido RailwaySapporo Hokkaido Japan o Hosp, Sapporo, Hokkaido, Japan
Titolo Testata:
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
fascicolo: 2, volume: 107, anno: 2001,
pagine: 331 - 336
SICI:
0091-6749(200102)107:2<331:IMRDAI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERFERON-GAMMA PRODUCTION; IFN-GAMMA; PERIPHERAL-BLOOD; ESCHERICHIA-COLI; ALLERGIC-ASTHMA; T-CELLS; INTERLEUKIN-18; CYTOKINE; EXPRESSION; HISTAMINE;
Keywords:
IL-18; IFN-gamma; IL-2 receptor; acute asthma; sarcoidosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Tanaka, H Sapporo Med Univ, Sch Med, Dept Internal Med 3, Chuo Ku, South 1,West 16, Sapporo, Hokkaido 0608543, Japan Sapporo Med Univ South 1,West 16Sapporo Hokkaido Japan 0608543
Citazione:
H. Tanaka et al., "IL-18 might reflect disease activity in mild and moderate asthma exacerbation", J ALLERG CL, 107(2), 2001, pp. 331-336

Abstract

Background: IL-18, identified as an IFN-gamma -inducing factor, is a proinflammatory cytokine that plays an important role in T(H)1 cell activation. Recently, it was reported that histamine induced IL-18 and that IL-18 mightact as a coinducer of T(H)1 and T(H)2 cytokines. Objective: The aim was to evaluate the contribution of IL-18 to asthma exacerbation. Methods: Serum IL-18, soluble IL-2 receptor, eosinophil cationic protein, and plasma IFN-gamma levels, as well as peak expiratory flow were measured in patients with stable asthma (n = 28), acute mild or moderate asthma (n =23), or pulmonary sarcoidosis (n = 35) and in healthy subjects (n = 26). We compared the serum IL-18 levels between patients with acute asthma and those in remission and examined the time course in acute exacerbation after asthma therapy. Results: Significantly higher serum IL-18 levels were found in patients with acute asthma (215 +/- 33 pg/mL, mean +/- SE; P = .02) and pulmonary sarcoidosis (239 +/- 27 pg/mL, P = .008) than in control subjects (127 +/- 11 pg/mL), but the plasma IFN-gamma level was significantly elevated in only pulmonary sarcoidosis (P < .001). In pulmonary sarcoidosis the IL-18 values significantly correlated with the IFN-<gamma> levels (r = 0.61, P < .001), but in acute asthma they did not. The IL-18 levels during acute asthma exacerbation were significantly higher (P = .01) than on remission days. In acute asthma, circulating IL-18 levels significantly correlated with serum soluble IL-2 receptor levels (r = 0.77, P < .0001) but not with serum eosinophil cationic protein levels. The IL-18 level had a tendency to inversely correlate with peak expiratory flow. The elevated IL-18 levels in acute asthma quickly decreased on day 3 (P = .02) and day 3 (P = .002) after therapy. Conclusion: It was suggested that IL-18 may play a potential role to activate immunologic responses and may reflect disease activity in mild and moderate asthma exacerbation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 19:10:04