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Titolo:
Neurotransmitters and signal transduction processes in bipolar affective disorders: a synopsis
Autore:
Ackenheil, M;
Indirizzi:
Univ Munich, Hosp Psychiat, D-80336 Munich, Germany Univ Munich Munich Germany D-80336 osp Psychiat, D-80336 Munich, Germany
Titolo Testata:
JOURNAL OF AFFECTIVE DISORDERS
fascicolo: 1-2, volume: 62, anno: 2001,
pagine: 101 - 111
SICI:
0165-0327(200101)62:1-2<101:NASTPI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; G-PROTEIN; DEPRESSED-PATIENTS; AFFECTIVE-ILLNESS; MOOD DISORDERS; BRAIN; ANTIDEPRESSANT; LITHIUM; LINKAGE; KINASE;
Keywords:
neurotransmitters; signal transduction processes; bipolar affective disorders;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Ackenheil, M Univ Munich, Hosp Psychiat, Nussbaumstr 7, D-80336 Munich, Germany Univ Munich Nussbaumstr 7 Munich Germany D-80336 ch, Germany
Citazione:
M. Ackenheil, "Neurotransmitters and signal transduction processes in bipolar affective disorders: a synopsis", J AFFECT D, 62(1-2), 2001, pp. 101-111

Abstract

New technologies have led to tremendous progress in understanding what today we call bipolar disorders, whose clinical diagnosis has been refined continuously since Kraepelin first described them. Molecular genetic studies have produced interesting findings, but to date have failed to identify specific genes that are so far responsible for the vulnerability to bipolar. disorders. Biochemical studies in combination with pharmacotherapy give hintsthat the neurotransmitter function and the related signal transduction maybe abnormally regulated. Since all the neurotransmitter circuits are interconnected, the dysregulation may occur on different levels and it is ratherimprobable that one single abnormality should account for the disorder. This paper reviews these promising developments. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 14:40:45