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Titolo:
Activation of Fc epsilon RI-positive eosinophils in bullous pemphigoid
Autore:
Kasahara-Imamura, M; Hosokawa, H; Maekawa, N; Horio, T;
Indirizzi:
Kansai Med Univ, Dept Dermatol, Moriguchi, Osaka 5708506, Japan Kansai MedUniv Moriguchi Osaka Japan 5708506 guchi, Osaka 5708506, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
fascicolo: 3, volume: 7, anno: 2001,
pagine: 249 - 253
SICI:
1107-3756(200103)7:3<249:AOFERE>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDERMAL LANGERHANS CELLS; HIGH-AFFINITY RECEPTOR; IGE RECEPTOR; EXPRESSION; ANTIGEN; PATIENT;
Keywords:
bullous pemphigoid; IgE; Fc epsilon RI; eosinophil; Langerhans cell;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Kasahara-Imamura, M Kansai Med Univ, Dept Dermatol, 10-15 Fumizono Cho, Moriguchi, Osaka 5708506, Japan Kansai Med Univ 10-15 Fumizono Cho Moriguchi Osaka Japan 5708506
Citazione:
M. Kasahara-Imamura et al., "Activation of Fc epsilon RI-positive eosinophils in bullous pemphigoid", INT J MOL M, 7(3), 2001, pp. 249-253

Abstract

Bullous pemphigoid (BP) is an autoimmune disease frequently occurring in elderly persons. It has been reported that 92-kDa gelatinase released from eosinophils cleaves the extracellular domain of BP180 protein, suggesting a direct role of eosinophils in bulla formation in this disease. The expression of the high-affinity IgE receptor, Fc epsilon RI, on eosinophils was examined in patient with BP. Samples of affected skin obtained from 7 patientswith BP were stained immunohistochemically by the alkaline phosphatase antialkaline phosphatase (APAAP) method and mirror sections were examined. Eosinophils were present at a rate of 1.0-19.0% in lesions of the dermis, and the number of IgE-positive cells exceeded that of Fc epsilon RI-positive cells in all cases. These cells were not detected in the epidermis, and examination of mirror sections confirmed that the Fc epsilon RI-positive cells corresponded to eosinophils. It has been demonstrated that Fc epsilon RI-positive cells are involved in the dermal lesions of BP. The activation of eosinophils by Fc epsilon RI may participate in the pathogenesis of BP by triggering the degranulation of mast cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 16:22:18