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Titolo:
The LMP1 gene isolated from Russian nasopharyngeal carcinoma has no 30-bp deletion
Autore:
Hahn, P; Novikova, E; Scherback, L; Janik, C; Pavlish, O; Arkhipov, V; Nicholls, J; Muller-Lantzsch, N; Gurtsevitch, V; Grasser, FA;
Indirizzi:
Univ Homburg, Abt Virol, Inst Med Mikrobiol & Hyg, Kliniken, D-66421 Homburg, Germany Univ Homburg Homburg Germany D-66421 Kliniken, D-66421 Homburg, Germany Russian Acad Med Sci, NN Blokhin Canc Res Ctr, Moscow, Russia Russian AcadMed Sci Moscow Russia Blokhin Canc Res Ctr, Moscow, Russia Univ Hong Kong, Queen Mary Hosp, Dept Pathol, Hong Kong, Hong Kong, Peoples R China Univ Hong Kong Hong Kong Hong Kong Peoples R China Kong, Peoples R China
Titolo Testata:
INTERNATIONAL JOURNAL OF CANCER
fascicolo: 6, volume: 91, anno: 2001,
pagine: 815 - 821
SICI:
0020-7136(20010315)91:6<815:TLGIFR>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPSTEIN-BARR-VIRUS; MEMBRANE PROTEIN-1 GENE; LATENT MEMBRANE-PROTEIN-1; SEQUENCE VARIATION; HONG-KONG; PREVALENCE; ONCOGENE; VARIANTS; CHINESE; POPULATION;
Keywords:
EBV; LMP1; NPC; 30-bp deletion; NFKB; jun/AP-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Grasser, FA Univ Homburg, Abt Virol, Inst Med Mikrobiol & Hyg, Kliniken, Gebaude 47, D-66421 Homburg, Germany Univ Homburg Gebaude 47 Homburg Germany D-66421 burg, Germany
Citazione:
P. Hahn et al., "The LMP1 gene isolated from Russian nasopharyngeal carcinoma has no 30-bp deletion", INT J CANC, 91(6), 2001, pp. 815-821

Abstract

The Epstein-Barr virus (EBV) is tightly linked to the induction of undifferentiated nasopharyngeal carcinoma (NPC), a tumour endemic in certain areasof southeast Asia. The LMPI gene encoded by EBV is a classical oncogene due to its ability to transform rodent fibroblasts. LMPI is absolutely essential for transformation of B cells by the virus and is one of the few EBV genes found to be expressed in NPC, It was originally shown that the LMPI gene from NPC harbours a deletion of 30 bp in the 3' part of the gene. However, this deletion is also present in the virus spread in healthy people of the areas endemic for NPC and also in other EBV-positive tumours as well as in healthy carriers. We isolated and sequenced the LMPI gene obtained from tissue of 7 Russian patients with NPC and I German patient with an NPC-like tumour of the parotid gland (PG) and compared them with the LMPI gene isolated from peripheral blood lymphocytes (PBLs) of 6 Russian and 4 German healthy EBV-positive carriers, Neither the Russian NPC cases nor the German NPC-like tumour harboured an LMPI gene with the 30-bp deletion, while I Russian and 2 German carriers contained the LMPI gene with the 30-bp deletion. Inaddition, the LMPI gene isolated from PBLs of the German patient was virtually identical to the gene isolated from the primary tumour, Functional analysis showed no correlation between the presence or absence of the 30-bp deletion and the level of induction of the transcription factors NF kappaB and jun/AP-I caused by LMP I. These data indicate that the 30-bp deletion is not a factor predisposing for NPC, Comparison of the DNA sequences revealedthat the LMPI genes present in the NPCs most likely represent the "strain"persisting in the general population. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:41:42