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Titolo:
ADAMTS: a novel family of extracellular matrix proteases
Autore:
Tang, BL;
Indirizzi:
Inst Mol & Cell Biol, Cent Imaging & Histol Facil, Singapore 117609, Singapore Inst Mol & Cell Biol Singapore Singapore 117609 gapore 117609, Singapore
Titolo Testata:
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
fascicolo: 1, volume: 33, anno: 2001,
pagine: 33 - 44
SICI:
1357-2725(200101)33:1<33:AANFOE>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; I N-PROTEINASE; METALLOPROTEINASE-DISINTEGRIN; CAENORHABDITIS-ELEGANS; THROMBOSPONDIN MOTIFS; ASTACIN FAMILY; C-PROTEINASE; TS FAMILY; PROCOLLAGEN; CLONING;
Keywords:
ADAMTS; metalloprotease; extracellular matrix; aggrecanase;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Tang, BL Inst Mol & Cell Biol, Cent Imaging & Histol Facil, 30 Med Dr, Singapore 117609, Singapore Inst Mol & Cell Biol 30 Med Dr Singapore Singapore 117609 gapore
Citazione:
B.L. Tang, "ADAMTS: a novel family of extracellular matrix proteases", INT J BIO C, 33(1), 2001, pp. 33-44

Abstract

ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) is anovel family of extracellular proteases found in both mammals and invertebrates. Members of the family may be distinguished from the ADAM (a disintegrin and metalloprotease) family members based on the multiple copies of thrombospondin 1-like repeats they carry. With at least nine members in mammals alone, the ADAMTS Family members are predicted by their structural domains to be extracellular matrix (ECM) proteins with a wide range of activitiesand functions distinct from members of the ADAM Family that are largely anchored on the cell surface, ADAMTS2 is a procollagen N-proteinase, and the mutations of its gene are responsible for Human Ehlers-Danlos syndrome typeVII C and bovine dermatosparaxis. ADAMTS4 and ADAMTS5 are aggrecanases implicated in the degradation of cartilage aggrecan in arthritic diseases. Other members of the ADAMTS family have also been implicated in roles during embryonic development and angiogenesis. Current and future studies on this emerging group of ECM proteases may provide important insights into developmental or pathological processes involving ECM remodeling. (C) 2001 ElsevierScience Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 13:08:44