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Titolo:
Interaction between the adrenal and the pineal gland in chronic experimental inflammation induced by BCG in mice
Autore:
Lopes, C; Mariano, M; Markus, RP;
Indirizzi:
Univ Sao Paulo, Dept Fisiol, Inst Biociencias, BR-05508900 Sao Paulo, Brazil Univ Sao Paulo Sao Paulo Brazil BR-05508900 BC05508900 Sao Paulo, Brazil Univ Fed Sao Paulo, Dept Microbiol Imunol & Parasitol, BR-04023900 Sao Paulo, Brazil Univ Fed Sao Paulo Sao Paulo Brazil BR-04023900 BC3900 Sao Paulo, Brazil
Titolo Testata:
INFLAMMATION RESEARCH
fascicolo: 1, volume: 50, anno: 2001,
pagine: 6 - 11
SICI:
1023-3830(200101)50:1<6:IBTAAT>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
MELATONIN SYNTHESIS; CIRCADIAN-RHYTHM; GLUCOCORTICOIDS; DEXAMETHASONE; RATS; INTERLEUKIN-6; EXPRESSION; ARTHRITIS; INHIBIT; GENE;
Keywords:
chronic inflammation; circadian rhythm; melatonin; adrenal gland; pineal gland;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Markus, RP Univ Sao Paulo, Dept Fisiol, Inst Biociencias, Rua do Matao Travessa 14,Cidade Univ, BR-05508900 Sao Paulo, Brazil Univ Sao Paulo Rua do Matao Travessa 14,Cidade Univ Sao Paulo Brazil BR-05508900 BC
Citazione:
C. Lopes et al., "Interaction between the adrenal and the pineal gland in chronic experimental inflammation induced by BCG in mice", INFLAMM RES, 50(1), 2001, pp. 6-11

Abstract

Objective: To investigate the adrenal gland influence on diurnal rhythm ofchronic inflammation induced by BCG in mice and its interaction with the pineal gland. Methods: C57B1/6 mice were injected with BCG in the footpad and maintainedin a 12/12 h light-dark cycle. Air the experimental manipulations were done after 20-45 days. Paw swelling was measured every 4 h for 48 or 72 h and decomposed by Fourier transformation. Vascular permeability was evaluated by Evans Blue overflow, in mice killed at midday or midnight. 6-Sulphatoxymelatonin urine concentration was determined by radioimmunoassay in samples taken during the dark or light phase. Results: Adrenalectomy or metyrapone treatment abolished the paw swelling diurnal. rhythm, the nocturnal reduction in vascular permeability, and the nocturnal increase in 6-sulphatoximelatonin in the urine. Nocturnal administration of melatonin to adrenalectomized mice restored the paw swelling diurnal variation and the reduction of vascular permeability of the inflamed paw. Conclusion: Adrenal cortical hormones are important for the maintenance ofthe diurnal rhythm of chronic inflammation (paw swelling and vascular permeability), probably by promoting a nocturnal surge of melatonin, which is the hormone that modulates the diurnal variation of chronic inflammation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 18:37:25