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Titolo:
Mycobacterium avium invades the intestinal mucosa primarily by interactingwith enterocytes
Autore:
Sangari, FJ; Goodman, J; Petrofsky, M; Kolonoski, P; Bermudez, LE;
Indirizzi:
Calif Pacific Med Ctr, Res Inst, Kuzell Inst Arthrit & Infect Dis, San Francisco, CA 94115 USA Calif Pacific Med Ctr San Francisco CA USA 94115 Francisco, CA 94115 USA Univ Calif San Francisco, Pediat Elect Microscopy Lab, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
INFECTION AND IMMUNITY
fascicolo: 3, volume: 69, anno: 2001,
pagine: 1515 - 1520
SICI:
0019-9567(200103)69:3<1515:MAITIM>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPITHELIAL-CELLS; ESCHERICHIA-COLI; SALMONELLA-TYPHIMURIUM; COMPLEX INFECTION; PEYERS-PATCHES; ATTACHMENT; INVASION; HOST; HT-29; AIDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Bermudez, LE Calif Pacific Med Ctr, Res Inst, Kuzell Inst Arthrit & InfectDis, 2200 Webster St,Suite 305, San Francisco, CA 94115 USA Calif Pacific Med Ctr 2200 Webster St,Suite 305 San Francisco CA USA 94115
Citazione:
F.J. Sangari et al., "Mycobacterium avium invades the intestinal mucosa primarily by interactingwith enterocytes", INFEC IMMUN, 69(3), 2001, pp. 1515-1520

Abstract

Previous studies have demonstrated that Mycobacterium avium can invade intestinal epithelial cells both in vitro and in vivo. When given to mice orally, M, avium preferentially interacts with the intestinal mucosa at the terminal ileum, We evaluated the mechanism(s) of M, avium binding and invasionof the intestinal mucosa using three different systems: (i) electron microscopy following administration of M, avium into an intestinal loop in mice,(ii) quantitative comparison of the bacterial load in Peyer's patch areas of the terminal ileum versus areas that do not contain Peyer's patches, and(iii) investigation of the ability of M. avium to cause disseminated infection following oral administration using B-cell-deficient mice, lacking Peyer's patches, in comparison with C57BL/6 black mice. By all approaches, M, avium was found to invade the intestinal mucosa by interacting primarily with enterocytes and not with M cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 07:16:54