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Titolo:
The CD19/CD21 complex functions to prolong B cell antigen receptor signaling from lipid rafts
Autore:
Cherukuri, A; Cheng, PC; Sohn, HW; Pierce, SK;
Indirizzi:
NIAID, Immunogenet Lab, NIH, Rockville, MD 20852 USA NIAID Rockville MD USA 20852 mmunogenet Lab, NIH, Rockville, MD 20852 USA Northwestern Univ, Dept Biochem Mol Biol & Cell Biol, Evanston, IL 60208 USA Northwestern Univ Evanston IL USA 60208 Cell Biol, Evanston, IL 60208 USA
Titolo Testata:
IMMUNITY
fascicolo: 2, volume: 14, anno: 2001,
pagine: 169 - 179
SICI:
1074-7613(200102)14:2<169:TCCFTP>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-DEPENDENT ANTIGEN; PHOSPHOLIPASE-C; LYMPHOCYTES-B; TRANSDUCTION MOLECULE; ACQUIRED-IMMUNITY; KINASE ACTIVATION; DOWN-REGULATION; CD19; IMMUNOGLOBULIN; PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Pierce, SK NIAID, Immunogenet Lab, NIH, Rockville, MD 20852 USA NIAID Rockville MD USA 20852 Lab, NIH, Rockville, MD 20852 USA
Citazione:
A. Cherukuri et al., "The CD19/CD21 complex functions to prolong B cell antigen receptor signaling from lipid rafts", IMMUNITY, 14(2), 2001, pp. 169-179

Abstract

The CD19/CD21 complex functions to significantly enhance B cell antigen receptor (BCR) signaling in response to complement-tagged antigens. Recent studies showed that following antigen binding the BCR translocates into plasma membrane lipid rafts that serve as platforms for BCR signaling. Here, we show that the binding of complement-tagged antigens stimulates the translocation of both the BCR and the CD19/ CD21 complex into lipid rafts, resulting in prolonged residency in and signaling from the rafts, as compared to BCR cross-linking alone. When coligated to the BCR, the CD19/CD21 complex retards the internalization and degradation of the BCR. The colocalization andstabilization of the BCR and the CD19/CD21 complex in plasma membrane lipid rafts represents a novel mechanism by which a coreceptor enhances BCR signaling.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 19:59:56