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Titolo:
ULBPs, novel MHC class I-related molecules bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor
Autore:
Cosman, D; Mullberg, J; Sutherland, CL; Chin, W; Armitage, R; Fanslow, W; Kubin, M; Chalupny, NJ;
Indirizzi:
Immunex Corp, Dept Biol Mol, Seattle, WA 98101 USA Immunex Corp Seattle WA USA 98101 p, Dept Biol Mol, Seattle, WA 98101 USA Immunex Corp, Dept Immunobiol, Seattle, WA 98101 USA Immunex Corp SeattleWA USA 98101 Dept Immunobiol, Seattle, WA 98101 USA
Titolo Testata:
IMMUNITY
fascicolo: 2, volume: 14, anno: 2001,
pagine: 123 - 133
SICI:
1074-7613(200102)14:2<123:UNMCIM>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER-CELLS; MAJOR HISTOCOMPATIBILITY COMPLEX; LEUCINE-ZIPPER; T-CELLS; B-CELLS; FAMILY; GENE; RECOGNITION; EXPRESSION; HOMOLOG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Cosman, D Immunex Corp, Dept Biol Mol, 51 Univ St, Seattle, WA 98101 USA Immunex Corp 51 Univ St Seattle WA USA 98101 attle, WA 98101 USA
Citazione:
D. Cosman et al., "ULBPs, novel MHC class I-related molecules bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor", IMMUNITY, 14(2), 2001, pp. 123-133

Abstract

The human cytomegalovirus glycoprotein, UL16, binds to two members of a novel family of molecules, the ULBPs, and to the MHC class I homolog, MICE. The ULBPs are GPI-linked glycoproteins belonging to the extended MHC class Ifamily but are only distantly related to MICE. The ULBP and MICE moleculesare ligands for the activating receptor, NKG2D/DAP10, and this interactionis blocked by a soluble form of UL16. The ULBPs stimulate cytokine and chemokine production from NK cells, and expression of ULBPs in NK cell-resistant target cells confers susceptibility to NK cell cytotoxicity. Masking of NK cell recognition of ULBP or MIC antigens by UL16 provides a potential mechanism by which human cytomegalovirus-infected cells might evade attack bythe immune system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 19:31:15