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Titolo:
The newer antiepileptic drugs: Their collective role and defining characteristics
Autore:
Anderson, GD; Miller, JW;
Indirizzi:
Univ Washington, Dept Pharm, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 n, Dept Pharm, Seattle, WA 98195 USA
Titolo Testata:
FORMULARY
fascicolo: 2, volume: 36, anno: 2001,
pagine: 114 -
SICI:
1082-801X(200102)36:2<114:TNADTC>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEWLY-DIAGNOSED EPILEPSY; COMPLEX PARTIAL SEIZURES; TONIC-CLONIC SEIZURES; QUALITY-OF-LIFE; SODIUM VALPROATE; DOUBLE-BLIND; GABAPENTIN THERAPY; WEIGHT-GAIN; LAMOTRIGINE; CARBAMAZEPINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Anderson, GD Univ Washington, Dept Pharm, Box 357630, Seattle, WA 98195 USA Univ Washington Box 357630 Seattle WA USA 98195 WA 98195 USA
Citazione:
G.D. Anderson e J.W. Miller, "The newer antiepileptic drugs: Their collective role and defining characteristics", FORMULARY, 36(2), 2001, pp. 114

Abstract

The utility of long-established antiepileptic drugs (AEDs) has been restricted by lack of efficacy in some patients, neurotoxicity, teratogenicity, idiosyncratic reactions, and complex pharmacokinetics. Eight new AEDs have been introduced in the United States since 1993 (felbamate, gabapentin, lamotrigine, levetiracetam, oxcarbazepine, tiagabine, topiramate, zonisamide). These newer AEDs offer both options for improved efficacy in the treatment of refractory seizures and the possibility of reducing or eliminating the adverse effects of older AEDs, Some of the newer AEDs are associated with less sedation, less weight gain, and possibly fewer endocrine effects. Moreover, the newer agents' fewer drug interactions offer greater ease of use. While the current role of the newer AEDs generally remains limited to second-line therapy, the many new options they have afforded clinicians are of considerable value, given the great variability of patient response to AED therapy. Because of this variability and the lack of data directly comparing the newer AEDs with one another, all of the newer AEDs should be available to patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:12:44