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Titolo:
Effects of a dual L/N-type Ca2+ channel blocker cilnidipine on neurally mediated chronotropic response in anesthetized dogs
Autore:
Konda, T; Takahara, A; Maeda, K; Dohmoto, H; Yoshimoto, R;
Indirizzi:
Ajinomoto Co Inc, Pharmaceut Res Labs, Kawasaki, Kanagawa 2108681, Japan Ajinomoto Co Inc Kawasaki Kanagawa Japan 2108681 Kanagawa 2108681, Japan
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1, volume: 413, anno: 2001,
pagine: 117 - 120
SICI:
0014-2999(20010209)413:1<117:EOADLC>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYMPATHETIC NEURONS; NERVOUS-SYSTEM; VASOCONSTRICTION; NOREPINEPHRINE; INFARCTION; RELEASE;
Keywords:
N-type Ca2+ channel; cilnidipine; bilateral carotid artery occlusion; vagal nerve stimulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Takahara, A Ajinomoto Co Inc, Pharmaceut Res Labs, 1-1 Suzuki-cho, Kawasaki, Kanagawa 2108681, Japan Ajinomoto Co Inc 1-1 Suzuki-cho Kawasaki Kanagawa Japan 2108681
Citazione:
T. Konda et al., "Effects of a dual L/N-type Ca2+ channel blocker cilnidipine on neurally mediated chronotropic response in anesthetized dogs", EUR J PHARM, 413(1), 2001, pp. 117-120

Abstract

We investigated the effects of an L-type and N-type Ca2+ channel blocker, cilnidipine, on neurally mediated chronotropic responses to clarify the anti-autonomic profile of cilnidipine in anesthetized dogs. Pretreatment with cilnidipine (0.3. 1.0 and 3.0 mug/kg, i.v.), which decreased mean blood pressure by 5 to 31 mm Hg, inhibited the changes in heart rate and plasma norepinephrine: concentration induced by bilateral carotid artery occlusion, whereas it had no effect on vagal nerve stimulation-induced bradycardia. These results suggest that antihypertensive and antisympathetic doses of cilnidipine fail to influence chronotropic responses mediated by parasympathetic nerve activation in the in vivo canine heart. (C) 2001 Elsevier science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:40:36