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Titolo:
The occ1 gene is preferentially expressed in the primary visual cortex in an activity-dependent manner: a pattern of gene expression related to the cytoarchitectonic area in adult macaque neocortex
Autore:
Tochitani, S; Liang, FY; Watakabe, A; Hashikawa, T; Yamamori, T;
Indirizzi:
Natl Inst Basic Biol, Div Speciat Mech 1, Aichi 4448585, Japan Natl Inst Basic Biol Aichi Japan 4448585 at Mech 1, Aichi 4448585, Japan Grad Univ Adv Studies, Dept Mol Biomech, Aichi 4448585, Japan Grad Univ Adv Studies Aichi Japan 4448585 Biomech, Aichi 4448585, Japan RIKEN, Brain Sci Inst, Lab Neural Architecture, Wako, Saitama 3510198, Japan RIKEN Wako Saitama Japan 3510198 chitecture, Wako, Saitama 3510198, Japan
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 2, volume: 13, anno: 2001,
pagine: 297 - 307
SICI:
0953-816X(200101)13:2<297:TOGIPE>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOLLISTATIN-RELATED PROTEIN; GLUTAMIC-ACID DECARBOXYLASE; MONOCLONAL-ANTIBODY CAT-301; LATERAL GENICULATE-NUCLEUS; OSTEOBLASTIC CELL-LINE; CYTOCHROME-OXIDASE; CEREBRAL-CORTEX; STRIATE CORTEX; DIFFERENTIAL EXPRESSION; REGIONAL SPECIFICATION;
Keywords:
differential display; occ1 (TSC-36/FRP); ocular dominance column; region-selective expression; visual deprivation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Yamamori, T Natl Inst Basic Biol, Div Speciat Mech 1, Aichi 4448585, JapanNatl Inst Basic Biol Aichi Japan 4448585 ichi 4448585, Japan
Citazione:
S. Tochitani et al., "The occ1 gene is preferentially expressed in the primary visual cortex in an activity-dependent manner: a pattern of gene expression related to the cytoarchitectonic area in adult macaque neocortex", EUR J NEURO, 13(2), 2001, pp. 297-307

Abstract

Marker molecules to visualize specific subsets of neurons are useful for studying the functional organization of the neocortex. One approach to identify such molecular markers is to examine the differences in molecular properties among morphologically and physiologically distinct neuronal cell types. We used differential display to compare mRNA expression in the anatomically and functionally distinct areas of the adult macaque neocortex. We found that a gene, designated occ1, was preferentially transcribed in the posterior region of the neocortex, especially in area 17. Complete sequence analysis revealed that occ1 encodes a macaque homolog of a secretable protein, TSC-36/follistatin-related protein (FRP). In situ hybridization histochemistry confirmed the characteristic neocortical expression pattern of occ1 andshowed that occ1 transcription is high in layers II, III, IVA and IVC of area 17. In addition, occ1 transcription was observed selectively in cells of the magnocellular layers in the lateral geniculate nucleus (LGN). Dual labeling immunohistochemistry showed that the occ1-positive neurons in area 17 include both gamma -aminobutyric acid (GABA)-positive aspiny inhibitory cells and the alpha -subunit of type II calcium/calmodulin-dependent proteinkinase (CaMKII alpha)-positive spiny excitatory cells. With brief periods of monocular deprivation, the occ1 mRNA level decreased markedly in deprived ocular dominance columns of area 17. From this we conclude that the expression of occ1 mRNA is present in a subset of neurons that are preferentially localized in particular laminae of area 17 and consist of various morphological and physiological neuronal types, and, furthermore, occ1 transcription is subject to visually driven activity-dependent regulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 13:11:53