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Titolo:
The anabolic-androgenic steroid nandrolone decanoate affects the density of dopamine receptors in the male rat brain
Autore:
Kindlundh, AMS; Lindblom, J; Bergstrom, L; Wikberg, JES; Nyberg, F;
Indirizzi:
Uppsala Univ, Dept Pharmaceut Biosci, Div Biol Res Drug Dependence, S-75124 Uppsala, Sweden Uppsala Univ Uppsala Sweden S-75124 Dependence, S-75124 Uppsala, Sweden Uppsala Univ, Div Pharmacol, S-75124 Uppsala, Sweden Uppsala Univ Uppsala Sweden S-75124 v Pharmacol, S-75124 Uppsala, Sweden
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 2, volume: 13, anno: 2001,
pagine: 291 - 296
SICI:
0953-816X(200101)13:2<291:TASNDA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS-ACCUMBENS; DRUG-ADDICTION; SUBSTANCE-P; MESOLIMBIC DOPAMINE; GENE-EXPRESSION; MESSENGER-RNAS; UNITED-STATES; ADOLESCENTS; ABUSE; RELEASE;
Keywords:
autoradiography; dopamine D-1-like receptors; dopamine D-2-like receptors; mesocorticolimibic pathway; nigrostriatal pathway; reward;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Kindlundh, AMS Uppsala Univ, Dept Pharmaceut Biosci, Div Biol Res Drug Dependence, Box 591 Biomedicum, S-75124 Uppsala, Sweden Uppsala Univ Box 591 Biomedicum Uppsala Sweden S-75124 den
Citazione:
A.M.S. Kindlundh et al., "The anabolic-androgenic steroid nandrolone decanoate affects the density of dopamine receptors in the male rat brain", EUR J NEURO, 13(2), 2001, pp. 291-296

Abstract

In recent years a male group of anabolic-androgenic steroid misusers has been identified to share socio-demographic and personality related background factors with misusers of psychotropic substances, as well as being involved in habits of multiple drug use. The present study aimed to assess whether anabolic-androgenic steroids (AAS) would affect the density of the dopamine receptors in areas implicated in reward and behaviour in the male rat brain. The effects of 2 weeks of treatment with i.m. injections of nandrolonedecanoate (15 mg/kg/day) on the expression of the D-1-like and D-2-like receptors were evaluated by autoradiography. Specific binding of D-1-like receptors was significantly down regulated in the caudate putamen, the nucleusaccumbens core and shell. D-2-like receptor densities were down regulated in the nucleus accumbens shell, but up regulated in the caudate putamen, the nucleus accumbens core and the ventral tegmental area. These results are compatible with nandrolone induced neuroadaptive alterations in dopamine circuits associated with motor functions and behavioural paradigms known to be affected following AAS misuse.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 06:54:46