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Titolo:
Stage-dependent changes in the modulation of spinal nociceptive neuronal activity during the course of inflammation
Autore:
Danziger, N; Weil-Fugazza, J; Le Bars, D; Bouhassira, D;
Indirizzi:
INSERM, U161, F-75014 Paris, France INSERM Paris France F-75014INSERM, U161, F-75014 Paris, France
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 2, volume: 13, anno: 2001,
pagine: 230 - 240
SICI:
0953-816X(200101)13:2<230:SCITMO>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSAL HORN NEURONS; NOXIOUS INHIBITORY CONTROLS; TONIC DESCENDING INHIBITION; RECEPTIVE-FIELD PROPERTIES; SPINOTHALAMIC TRACT CELLS; FOS PROTEIN EXPRESSION; CONVERGENT NEURONS; ACUTE ARTHRITIS; UNILATERAL INFLAMMATION; PERIPHERAL INFLAMMATION;
Keywords:
arthritis; descending controls; diffuse noxious inhibitory controls; nociception; pain modulation; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Bouhassira, D INSERM, U161, 2 Rue Alesia, F-75014 Paris, France INSERM 2 Rue Alesia Paris France F-75014 5014 Paris, France
Citazione:
N. Danziger et al., "Stage-dependent changes in the modulation of spinal nociceptive neuronal activity during the course of inflammation", EUR J NEURO, 13(2), 2001, pp. 230-240

Abstract

Spinal and supraspinal controls can tonically or phasically modulate the output of spinal nociceptive neurons. Alterations of these modulatory systems have been described during the acute stage of inflammation. In the present study in the rat, tonic descending controls were assessed during acute (24-48 h) and chronic (3-4 weeks) stages of monoarthritis of the ankle. The electrophysiological properties of spinal convergent neurons with ankle input were compared before and after spinalization. In a parallel series of experiments, spinal convergent neurons were recorded from the normal side in order to assess the propriospinal and supraspinal inhibitory controls triggered by nociceptive stimulation of the inflamed ankle. Tonic descending inhibition of convergent neurons with input from the inflamed ankle was enhanced during the acute stage and then decreased during the chronic stage of monoarthritis. Contralateral-induced inhibitions exhibited a similar temporal evolution. Time-dependent changes in the spinal transmission of nociceptivesignals were shown by removing descending modulation in animals with monoarthritis; sensitization of spinal neurons with input from the inflamed ankle was demonstrated during the acute stage of monoarthritis, whereas a crossed transmission between inflamed and normal sides was observed during the chronic stage of the disease. These results show that dynamic and stage-dependent modifications of descending controls tend to dampen the central changes associated with inflammation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 23:56:28