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Titolo:
Functional projection distances of spinal interneurons mediating reciprocal inhibition during swimming in Xenopus tadpoles
Autore:
Soffe, SR; Zhao, FY; Roberts, A;
Indirizzi:
Univ Bristol, Sch Biol Sci, Bristol BS8 1UG, Avon, England Univ Bristol Bristol Avon England BS8 1UG Bristol BS8 1UG, Avon, England
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 3, volume: 13, anno: 2001,
pagine: 617 - 627
SICI:
0953-816X(200102)13:3<617:FPDOSI>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL PATTERN GENERATOR; RHYTHMIC MOTOR PATTERNS; INTERSEGMENTAL COORDINATION; COMMISSURAL INTERNEURONS; SYNAPTIC-INTERACTIONS; COUPLED OSCILLATORS; FICTIVE LOCOMOTION; LAMPREY; CORD; EMBRYOS;
Keywords:
coordination; glycinergic; locomotion; pattern-generation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Soffe, SR Univ Bristol, Sch Biol Sci, Woodland Rd, Bristol BS8 1UG, Avon, England Univ Bristol Woodland Rd Bristol Avon England BS8 1UG n, England
Citazione:
S.R. Soffe et al., "Functional projection distances of spinal interneurons mediating reciprocal inhibition during swimming in Xenopus tadpoles", EUR J NEURO, 13(3), 2001, pp. 617-627

Abstract

The basis for longitudinal coordination among spinal neurons during locomotion is still poorly understood. We have now examined the functional projection distances for the longitudinal axons of reciprocal inhibitory 'commissural interneurons' in the spinal cord of young Xenopus tadpoles. In quiescent animals, glycinergic inhibitory postsynaptic potentials (IPSPs) were evoked in ventral spinal neurons by stimulating small rostral and caudal groups of commissural interneuron somata at different distances on the opposite side of the hindbrain and spinal cord. Unitary IPSPs, produced by single synaptic contacts, could be distinguished from background noise. Local cord stimulation at different distances revealed maximum functional projection distances up to similar to 0.5 mm for both descending and ascending axons, but with the probability of recording connections falling steeply over this distance. These maximum longitudinal projection distances are smaller than predicted by axonal anatomy (similar to 1.2 mm). We then measured functionalprojection distances during swimming by examining the synaptic output of asurgically isolated group of rostral commissural interneurons, mapping theoccurrence of the mid-cycle, reciprocal IPSPs they produced in more caudalneurons. IPSPs occurred with high probability up to 0.9 mm away, nearly twice the projection distance found in quiescent tadpoles. These results showthat synaptic contacts from commissural interneurons could influence longitudinal coupling during swimming at distances of up to 0.9 mm (similar to 4-5 myotome segments or similar to 25% of the spinal cord). They provide direct evidence for functional projection distances of a characterized class of interneurons belonging to a spinal locomotor pattern generator.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 10:15:11