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Titolo:
Influence of injury and cytokines on synthesis of monocyte chemoattractantprotein-1 mRNA in peripheral nervous tissue
Autore:
Subang, MC; Richardson, PM;
Indirizzi:
Montreal Gen Hosp, Res Inst, Montreal, PQ H3G 1A4, Canada Montreal Gen Hosp Montreal PQ Canada H3G 1A4 Montreal, PQ H3G 1A4, Canada McGill Univ, Montreal, PQ H3G 1A4, Canada McGill Univ Montreal PQ Canada H3G 1A4 Univ, Montreal, PQ H3G 1A4, Canada
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 3, volume: 13, anno: 2001,
pagine: 521 - 528
SICI:
0953-816X(200102)13:3<521:IOIACO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; NF-KAPPA-B; SCHWANN-CELL PROLIFERATION; WALLERIAN DEGENERATION; GROWTH-FACTOR; ENDOTHELIAL-CELLS; ACTIVATING FACTOR; GENE-EXPRESSION; MESSENGER-RNA; FACTOR-ALPHA;
Keywords:
NF-kappa B; p38; rat sciatic nerves; Schwann cells; tumour necrosis factor-alpha;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Richardson, PM Royal London Hosp, Acad Dept Neurosurg, London E1 1BB, England Royal London Hosp London England E1 1BB n E1 1BB, England
Citazione:
M.C. Subang e P.M. Richardson, "Influence of injury and cytokines on synthesis of monocyte chemoattractantprotein-1 mRNA in peripheral nervous tissue", EUR J NEURO, 13(3), 2001, pp. 521-528

Abstract

The signals and the source of the signals for monocyte/macrophage entry into the injured peripheral nervous tissue are not yet defined. This study was undertaken to determine the distribution of the chemokine monocyte chemoattractant protein-1 mRNA in injured rat and mouse nerves and to investigatethe mechanisms that regulate its synthesis in rat Schwann cells. Results from RNase protection assays showed that, following sciatic nerve transection in rats, mRNA for monocyte chemoattractant protein-1 was induced at the site of lesion within 3 h of surgery and in more distal segments from 24 h for at least 8 days. In cultured Schwann cells, tumour necrosis factor-alphabut not interleukin-1 beta, interleukin-6, transforming growth factor-beta1, platelet-derived growth factor-BB or nerve growth factor induced monocyte chemoattractant protein-1 mRNA in a time- and dose-dependent fashion. Theinduction of monocyte chemoattractant protein-1 mRNA in Schwann cells treated with tumour necrosis factor-alpha was reduced by inhibitors of nuclear factor-kappaB and the p38 mitogen-activated protein kinase. In mice that lack the two receptors for tumour necrosis factor, the message for JE, a murine homologue of monocyte chemoattractant protein-1, was still induced within 6 h of injury at the lesion site. However, in more distal segments 4 daysafter transection the concentration of JE mRNA was lower than that of control mice. Tumor necrosis factor-alpha is the only cytokine that was shown to induce monocyte chemoattractant protein-1 mRNA in cultured Schwann cells and is one of the factors that regulate the synthesis of monocyte chemoattractant protein-1 in injured nerves.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 20:45:32