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Titolo:
NMDA receptor antagonist treatment induces a long-lasting increase in the number of proliferating cells, PSA-NCAM-immunoreactive granule neurons and radial glia in the adult rat dentate gyrus
Autore:
Nacher, J; Rosell, DR; Alonso-Llosa, G; McEwen, BS;
Indirizzi:
Rockefeller Univ, Neuroendocrinol Lab, New York, NY 10021 USA Rockefeller Univ New York NY USA 10021 crinol Lab, New York, NY 10021 USA Univ Valencia, Dept Cell Biol, E-46100 Valencia, Spain Univ Valencia Valencia Spain E-46100 Cell Biol, E-46100 Valencia, Spain
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 3, volume: 13, anno: 2001,
pagine: 512 - 520
SICI:
0953-816X(200102)13:3<512:NRATIA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIPPOCAMPAL-FORMATION; ADHESION MOLECULE; MAMMALIAN BRAIN; NERVOUS-SYSTEM; STEM-CELLS; NEUROGENESIS; MIGRATION; MONKEY; MOUSE; ACID;
Keywords:
5 ' BrdU; nestin; neurogenesis; neuronal migration; PSA-NCAM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Nacher, J Rockefeller Univ, Neuroendocrinol Lab, 1230 York Ave, New York, NY 10021 USA Rockefeller Univ 1230 York Ave New York NY USA 10021 Y 10021 USA
Citazione:
J. Nacher et al., "NMDA receptor antagonist treatment induces a long-lasting increase in the number of proliferating cells, PSA-NCAM-immunoreactive granule neurons and radial glia in the adult rat dentate gyrus", EUR J NEURO, 13(3), 2001, pp. 512-520

Abstract

During adulthood, neural precursors located in the subgranular zone of thedentate gyrus continue to proliferate, leading to the generation of new granule neurons. These recently generated cells transiently express the polysialylated form of the neural cell adhesion molecule, PSA-NCAM, and are supported by radial glia-like cells that are likely to play a role in neuronal migration and differentiation, or even act as their precursors. Previous reports indicate that treatment with NMDA receptor antagonists stimulates adult neurogenesis in the dentate gyrus, and because of the potential therapeutic value of this approach, we were interested in further characterizing the consequences of pharmacologically modulating this process. We treated adult rats with the competitive NMDA receptor antagonist, CGP43487, and examined cell proliferation, PSA-NCAM expression, and changes in the radial glia cell population in the subgranular zone at different time points. In addition, we sought to determine if this treatment led to changes in cell death or gliotic reactions. The number of proliferating cells in the subgranular region of the dentate gyrus was increased significantly 2 days after treatment and it remained elevated 7 days postinjection. PSA-NCAM-immunoreactive granule cells and nestin-expressing radial glia-like cells also increased innumber 7 days after the treatment. In contrast, we did not observe any change in granule cell death, and we were unable to detect any microglial or astroglial reaction during the first 7 days after treatment. Thus, NMDA receptor antagonist treatment serves as a valuable tool to increase neurogenesis in the adult hippocampus without undesirable collateral deleterious effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 10:09:35