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Titolo:
Distribution of transcripts for the brain-specific GDP/GTP exchange factorcollybistin in the developing mouse brain
Autore:
Kneussel, M; Engelkamp, D; Betz, H;
Indirizzi:
Max Planck Inst Brain Res, Dept Neurochem, D-60528 Frankfurt, Germany Max Planck Inst Brain Res Frankfurt Germany D-60528 8 Frankfurt, Germany Max Planck Inst Brain Res, Dept Neuroanat, D-60528 Frankfurt, Germany Max Planck Inst Brain Res Frankfurt Germany D-60528 8 Frankfurt, Germany
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 3, volume: 13, anno: 2001,
pagine: 487 - 492
SICI:
0953-816X(200102)13:3<487:DOTFTB>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT SPINAL-CORD; GAMMA-AMINOBUTYRIC ACID; SUBUNIT MESSENGER-RNAS; GLYCINE-RECEPTOR; PROTEIN GEPHYRIN; CELL-MIGRATION; EXPRESSION; GTPASES; COLOCALIZATION; CYTOSKELETON;
Keywords:
DH domain; GABA(A) receptor; GDP/GTP exchange factor; gephyrin; glycine receptor; hPEM-2; PH domain; receptor clustering; SH3 domain; synaptogenesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Kneussel, M Max Planck Inst Brain Res, Dept Neurochem, Deutschordenstr 46,D-60528 Frankfurt, Germany Max Planck Inst Brain Res Deutschordenstr 46 Frankfurt Germany D-60528
Citazione:
M. Kneussel et al., "Distribution of transcripts for the brain-specific GDP/GTP exchange factorcollybistin in the developing mouse brain", EUR J NEURO, 13(3), 2001, pp. 487-492

Abstract

The dbl-like GDP/GTP exchange factor, collybistin, binds to the receptor anchoring protein gephyrin and activates the Rho-like GTPase Cdc42. Collybistin was found in two splice variants I and II, both of which share a tandemDbl homology/pleckstrin homology (DH/PH) domain. In heterologous expression systems, collybistin II induces the formation of submembraneous gephyrin aggregates and therefore has been implicated in inhibitory synapse formation. Expression of collybistin is restricted to neuronal tissues and is predominantly found in brain. Here, we investigated the spatio-temporal distribution of collybistin transcripts in the embryonic mouse brain and compared it to gephyrin and glycine receptor mRNA patterns. Our data show that collybistin expression is upregulated when neurons become postmitotic and start to differentiate.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 08:28:30