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Titolo:
Differential expression of fibroblast growth factor-2 and fibroblast growth factor receptor 1 in a scarring and nonscarring model of CNS injury in the rat
Autore:
Smith, C; Berry, M; Clarke, WE; Logan, A;
Indirizzi:
Univ Birmingham, Dept Med, Birmingham B15 2TT, W Midlands, England Univ Birmingham Birmingham W Midlands England B15 2TT W Midlands, England Ctr Neurosci, London SE1 9RT, England Ctr Neurosci London England SE1 9RT tr Neurosci, London SE1 9RT, England
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 3, volume: 13, anno: 2001,
pagine: 443 - 456
SICI:
0953-816X(200102)13:3<443:DEOFGF>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; TRANSIENT FOREBRAIN ISCHEMIA; FACTOR BFGF INJECTION; MESSENGER-RNA; ASTROCYTE PROLIFERATION; ASTROGLIAL RESPONSE; CEREBRAL HEMISPHERE; HIPPOCAMPAL-NEURONS; TRANSGENIC MICE; GENE-EXPRESSION;
Keywords:
brain injury; development; glial scarring; growth factors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Logan, A Univ Birmingham, Dept Med, Birmingham B15 2TT, W Midlands, England Univ Birmingham Birmingham W Midlands England B15 2TT s, England
Citazione:
C. Smith et al., "Differential expression of fibroblast growth factor-2 and fibroblast growth factor receptor 1 in a scarring and nonscarring model of CNS injury in the rat", EUR J NEURO, 13(3), 2001, pp. 443-456

Abstract

Injury to the adult brain results in abortive axon regeneration and the deposition of a dense fibrous glial scar. Therapeutic strategies to promote postinjury axon regeneration are likely to require antiscarring strategies. In neonatal brain wounds, scar material is not laid down and axons grow across the lesion site, either by de novo growth or regeneration. To achieve the therapeutic goal of recapitulating the nonscarring neonatal response in the injured adult, an understanding of how ontogenic differences in scarring reflect developmental diversities in the trophic response to injury is required. Fibrobast growth factor-2 (FGF-2) expression is developmentally regulated and has been implicated as a regulator of the wounding response of the adult rat central nervous system. We have investigated the expression ofFGF-2 and fibroblast growth factor receptor 1 (FGFR1) after penetrating lesions to the cerebral cortex of 5 days post partum (dpp) (nonscarring) and 16 dpp and adult (scarring) rats. In situ hybridization, immunohistochemistry and Western blotting showed robust and sustained increases in FGF-2 and FGFR1 mRNA and protein in reactive astrocytes around the lesion in scarringrats, a response that was attenuated substantially in the nonscarring neonate. These results demonstrate that changes in astrocyte FGF-2 and FGFR1 expression are coincident with the establishment of a mature pattern of glialscarring after injury in the maturing central nervous system, but it is premature to infer a causal relationship without further experiments.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 15:31:58