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Titolo:
Histamine prevents polyamine accumulation in mouse C57.1 mast cell cultures
Autore:
Fajardo, I; Urdiales, JL; Paz, JC; Chavarria, T; Sanchez-Jimenez, F; Medina, MA;
Indirizzi:
Univ Malaga, Fac Sci, Dept Mol Biol & Biochem, E-29071 Malaga, Spain Univ Malaga Malaga Spain E-29071 l Biol & Biochem, E-29071 Malaga, Spain
Titolo Testata:
EUROPEAN JOURNAL OF BIOCHEMISTRY
fascicolo: 3, volume: 268, anno: 2001,
pagine: 768 - 773
SICI:
0014-2956(200102)268:3<768:HPPAIM>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPERMIDINE SPERMINE N1-ACETYLTRANSFERASE; ORNITHINE DECARBOXYLASE; HISTIDINE-DECARBOXYLASE; MEMBRANE-VESICLES; MAMMALIAN-CELLS; INDUCTION; TRANSPORT; CANCER; N-1-ACETYLTRANSFERASE; GROWTH;
Keywords:
histamine; histidine decarboxylase; polyamines; ornithine decarboxylase; mast cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Medina, MA Univ Malaga, Fac Sci, Dept Mol Biol & Biochem, Campus Teatinos,E-29071 Malaga, Spain Univ Malaga Campus Teatinos Malaga Spain E-29071 Malaga, Spain
Citazione:
I. Fajardo et al., "Histamine prevents polyamine accumulation in mouse C57.1 mast cell cultures", EUR J BIOCH, 268(3), 2001, pp. 768-773

Abstract

The effects of histamine on polyamine uptake and metabolism was studied ina mouse mat cell line (C57.1), as a cell model in which bot biogenic amines are important for maintaining cell function and viability. Results obtained after incubations with exogenous histamine indicated that histamine prevents polyamine accumulation by affecting polyamine uptake. A plasma membrane transport system for polyamines has been also studied in:mast cells. It seems to be a Na+-dependent uptake with high affinity for both spermine and spermidine and lower affinity for putrescine and agmatine. Polyamine uptakewas reduced in both cells treated with exogenous histamine and histamine-preloaded cells. However, ornithine decarboxylase activity and cell proliferation were not affected by histamine. Incubation with histamine enhanced the spermidine/spermine acetyl transferase induction caused by N-1-ethyl-N-11-[(cyclopropyl)methyl]-4,8-diazaundecane, suggesting that polyamine acetylation could be another mechanism by which histamine prevents polyamine accumulation in C57.1 mast cells.

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Documento generato il 14/07/20 alle ore 12:29:52