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Titolo:
Lack of evidence of endogenous avian leukosis virus and endogenous avian retrovirus transmission to measles, mumps, and rubella vaccine recipients
Autore:
Hussain, AI; Shanmugam, V; Switzer, WM; Tsang, SX; Fadly, A; Thea, D; Helfand, R; Bellini, WJ; Folks, TM; Heneine, W;
Indirizzi:
Ctr Dis Control & Prevent, Atlanta, GA 30333 USA Ctr Dis Control & Prevent Atlanta GA USA 30333 ent, Atlanta, GA 30333 USA USDA, Avian Dis & Oncol Lab, E Lansing, MI USA USDA E Lansing MI USAUSDA, Avian Dis & Oncol Lab, E Lansing, MI USA Harvard Inst Int Dev, Cambridge, MA USA Harvard Inst Int Dev Cambridge MAUSA rd Inst Int Dev, Cambridge, MA USA
Titolo Testata:
EMERGING INFECTIOUS DISEASES
fascicolo: 1, volume: 7, anno: 2001,
pagine: 66 - 72
SICI:
1080-6040(200101/02)7:1<66:LOEOEA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
REVERSE-TRANSCRIPTASE ACTIVITY; CANCER RISK; SUBGROUP-E; RNA; CELLS; EAV-0;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Heneine, W Ctr Dis Control & Prevent, 1600 Clifton Rd,Mail Stop G19, Atlanta, GA 30333 USA Ctr Dis Control & Prevent 1600 Clifton Rd,Mail Stop G19 Atlanta GA USA 30333
Citazione:
A.I. Hussain et al., "Lack of evidence of endogenous avian leukosis virus and endogenous avian retrovirus transmission to measles, mumps, and rubella vaccine recipients", EM INFECT D, 7(1), 2001, pp. 66-72

Abstract

The identification of endogenous avian leukosis virus (ALV) and endogenousavian retrovirus (EAV) in chick cell-derived measles and mumps vaccines incurrent use has raised concern about transmission of these retroviruses tovaccine recipients. We used serologic and molecular methods to analyze specimens from 206 recipients of measles, mumps, and rubella (MMR) vaccine forevidence of infection with ALV and EAV. A Western blot assay for detectingantibodies to endogenous ALV was developed and validated. All serum samples were negative for antibodies to endogenous ALV by Western blot analysis. Peripheral blood lymphocyte samples from 100 vaccinees were further tested by polymerase chain reaction for both ALV and EAV proviral sequences; all were negative. Matching serum samples were tested by reverse transcriptase polymerase chain reaction for ALV and EAV RNA, and all 100 samples were negative, providing no evidence of viremia. These findings do not indicate the presence of either ALV or EAV infection in MMR vaccine recipients and provide support for current immunization policies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 23:54:49