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Titolo:
Blood flow assessment by ultrasound-induced destruction of echocontrast agents using harmonic power Doppler imaging: Which parameters determine contrast replenishment curves?
Autore:
Koster, J; Schlosser, T; Pohl, C; Lentz, C; Lohmaier, S; Veltmann, C; Kuntz-Hehner, S; Omran, H; Luderitz, B; Becher, H; Tiemann, K;
Indirizzi:
Univ Bonn, Dept Cardiol, D-53105 Bonn, Germany Univ Bonn Bonn Germany D-53105 Bonn, Dept Cardiol, D-53105 Bonn, Germany
Titolo Testata:
ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES
fascicolo: 1, volume: 18, anno: 2001,
pagine: 1 - 8
SICI:
0742-2822(200101)18:1<1:BFABUD>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
STIMULATED ACOUSTIC-EMISSION; MYOCARDIAL PERFUSION; ECHOCARDIOGRAPHY; MICROBUBBLES; QUANTIFICATION; INJECTION; SHIFTS;
Keywords:
contrast echocardiography; negative bolus technique; tissue blood flow measurement; harmonic power Doppler; stimulated acoustic emission;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Tiemann, K Univ Bonn, Dept Cardiol, Sigmund Freud Str 25, D-53105 Bonn, Germany Univ Bonn Sigmund Freud Str 25 Bonn Germany D-53105 n, Germany
Citazione:
J. Koster et al., "Blood flow assessment by ultrasound-induced destruction of echocontrast agents using harmonic power Doppler imaging: Which parameters determine contrast replenishment curves?", ECHOCARDIOG, 18(1), 2001, pp. 1-8

Abstract

Objective: To evaluate the feasibility of flow determinations by contrast replenishment using harmonic power Doppler imaging (H-PDI). Background: Theapplication of indicator dilution principles on contrast echocardiography is limited by numerous methodical problems. Recently, a new method was introduced that relies on ultrasound-mediated microbubble destruction and evaluation of the contrast replenishment. Methods: Definity, a perfluorocarbon-derived contrast agent under development, was continuously infused into a steady flow phantom and H-PDI registrations were performed within a silicone tube (d = 8 mm). Replenishment interval between destruction and imaging frame was varied from 0.04-2 seconds. Nonlinear curve fitting was performed using an exponential mathematical model. Results: Strong linear correlation between contrast dose and maximum signal intensity as well as between flow and the slope variable beta of the replenishment curve was found for all settings (r > 0.96). Maximum signal intensity and contrast replenishment rate were found to be a function of emission power and were significantly influenced by depth and focus position. Conclusion: The feasibility of flow assessment using replenishment curves obtained by H-PDI was demonstrated. However in experimental conditions, flow analysis was severely influenced by ultrasound system settings and imaging conditions such as emission power sound field geometry, and investigation depth. For a clinical use of this promising approach, algorithms that take specific system settings and imaging conditions into account have to be found. Imaging modalities that enable a mosthomogeneous scan field are best suited for the assessment of contrast replenishment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 04:37:37