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Titolo:
Distinct cortical migrations from the medial and lateral ganglionic eminences
Autore:
Anderson, SA; Marin, O; Horn, C; Jennings, K; Rubenstein, JLR;
Indirizzi:
Univ Calif San Francisco, Dept Psychiat, Nina Ireland Lab Dev Neurosci, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
DEVELOPMENT
fascicolo: 3, volume: 128, anno: 2001,
pagine: 353 - 363
SICI:
0950-1991(200102)128:3<353:DCMFTM>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
GABA-IMMUNOREACTIVE NEURONS; RAT VISUAL-CORTEX; CEREBRAL-CORTEX; CELL-MIGRATION; SONIC HEDGEHOG; ULTRASTRUCTURAL ANALYSIS; GABAERGIC INTERNEURONS; SUBVENTRICULAR ZONE; MOUSE TELENCEPHALON; VENTRAL FOREBRAIN;
Keywords:
cortex; interneuron; neuronal migration; GABA; ganglionic eminence; neuropeptide Y; subventricular zone; mouse;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Rubenstein, JLR Univ Calif San Francisco, Dept Psychiat, Nina Ireland Lab Dev Neurosci, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 3 USA
Citazione:
S.A. Anderson et al., "Distinct cortical migrations from the medial and lateral ganglionic eminences", DEVELOPMENT, 128(3), 2001, pp. 353-363

Abstract

Recent evidence suggests that projection neurons and interneurons of the cerebral cortex are generally derived from distinct proliferative zones. Cortical projection neurons originate from the cortical ventricular zone (VZ),and then migrate radially into the cortical mantle, whereas most cortical interneurons originate from the basal telencephalon and migrate tangentially into the developing cortex. Previous studies using methods that label both proliferative and postmitotic cells have found that cortical interneuronsmigrate from two major subdivisions of the developing basal telencephalon:the medial and lateral ganglionic eminences (MGE and LGE), Since these studies labeled cells by methods that do not distinguish between the proliferating cells and those that may have originated elsewhere, we have studied the contribution of the MGE and LGE to cortical interneurons using fate mapping and genetic methods. Transplantation of BrdU-labeled MGE or LGE neuroepithelium into the basal telencephalon of unlabeled telencephalic slices enabled us to follow the fate of neurons derived from each of these primordia, We have determined that early in neurogenesis GABA-expressing cells from the MGE tangentially migrate into the cerebral cortex, primarily via the intermediate zone, whereas cells from the LGE do not. Later in neurogenesis, LGE-derived cells also migrate into the cortex, although this migration occurs primarily through the subventricular zone. Some of these LGE-derived cells invade the cortical plate and express GABA, while others remain within the cortical proliferative zone and appear to become mitotically active late in gestation. In addition, by comparing the phenotypes of mouse mutants with differential effects on MGE and LGE migration, we provide evidence that the MGE and LGE may give rise to different subtypes of cortical interneurons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 01:18:53