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Titolo:
Cerebrospinal fluid tau levels increase with age in healthy individuals
Autore:
Blomberg, M; Jensen, M; Basun, H; Lannfelt, L; Wahlund, LO;
Indirizzi:
Huddinge Univ Hosp, Karolinska Inst, Div Geriatr Med,NEUROTEC, Dept Clin Neurosci Occupat Therapy & Elderly Care, S-14186 Huddinge, Sweden Huddinge Univ Hosp Huddinge Sweden S-14186 are, S-14186 Huddinge, Sweden
Titolo Testata:
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
fascicolo: 2, volume: 12, anno: 2001,
pagine: 127 - 132
SICI:
1420-8008(200103/04)12:2<127:CFTLIW>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
APOLIPOPROTEIN-E GENOTYPE; EARLY ALZHEIMERS-DISEASE; E ALLELE EPSILON-4; PROTEIN TAN; DEMENTIA; ESTABLISHMENT; DIAGNOSIS; MARKER;
Keywords:
tau protein; cerebrospinal fluid; apolipoprotein E; genotype; Alzheimer's disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Blomberg, M Huddinge Univ Hosp, Karolinska Inst, Div Geriatr Med,NEUROTEC,Dept Clin Neurosci Occupat Therapy & Elderly Care, S-14186 Huddinge, Sweden Huddinge Univ Hosp Huddinge Sweden S-14186 Huddinge, Sweden
Citazione:
M. Blomberg et al., "Cerebrospinal fluid tau levels increase with age in healthy individuals", DEMENT G C, 12(2), 2001, pp. 127-132

Abstract

Cerebrospinal fluid (CSF) tau is a promising biochemical ante-mortem marker for Alzheimer's disease (AD). Levels are increased in AD compared to other dementias, neurological diseases and healthy controls. An age-related decrease in both soluble tau and tau bound to paired helical filaments has been shown in brains from non-demented subjects. To study tau levels in normalageing, we investigated CSF in 29 healthy individuals aged 45-80 years, A statistically significant increase in CSF tau with increasing age was foundwhich might be caused by neuronal loss during normal ageing and redistribution of soluble tau from the brain into CSF, We could not demonstrate any influence by the APOE genotype, though larger populations have to be investigated to confirm this result. in conclusion, we found an age-dependent increase in CSF tau in healthy individuals, We emphasise the importance of establishing an age-dependent interval of CSF tau in non-demented subjects. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:03:27