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Titolo:
Senile dementia of the neurofibrillary tangle type: A comparison with Alzheimer's disease
Autore:
Yamada, M; Itoh, Y; Sodeyama, N; Suematsu, N; Otomo, E; Matsushita, M; Mizusawa, H;
Indirizzi:
Kanazawa Univ, Sch Med, Dept Neurol, Kanazawa, Ishikawa 9208640, Japan Kanazawa Univ Kanazawa Ishikawa Japan 9208640 wa, Ishikawa 9208640, Japan Tokyo Med & Dent Univ, Dept Neurol, Tokyo 113, Japan Tokyo Med & Dent Univ Tokyo Japan 113 niv, Dept Neurol, Tokyo 113, Japan Yokufukai Geriatr Hosp, Dept Internal Med, Tokyo, Japan Yokufukai Geriatr Hosp Tokyo Japan osp, Dept Internal Med, Tokyo, Japan Yokufukai Geriatr Hosp, Dept Pathol, Tokyo, Japan Yokufukai Geriatr Hosp Tokyo Japan iatr Hosp, Dept Pathol, Tokyo, Japan Tokyo Inst Psychiat, Dept Neuropathol, Tokyo, Japan Tokyo Inst Psychiat Tokyo Japan sychiat, Dept Neuropathol, Tokyo, Japan
Titolo Testata:
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
fascicolo: 2, volume: 12, anno: 2001,
pagine: 117 - 126
SICI:
1420-8008(200103/04)12:2<117:SDOTNT>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRESSIVE SUPRANUCLEAR PALSY; PREDOMINANT FORM; TAU-GENE; NEURONAL LOSS; SUBSET; INVOLVEMENT; MUTATIONS; PATHOLOGY; PLAQUES; ALLELE;
Keywords:
dementia; elderly; neurofibrillary tangle; Alzheimer's disease; hippocampus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Yamada, M Kanazawa Univ, Sch Med, Dept Neurol, 13-1 Takaramachi, Kanazawa,Ishikawa 9208640, Japan Kanazawa Univ 13-1 Takaramachi Kanazawa Ishikawa Japan 9208640 n
Citazione:
M. Yamada et al., "Senile dementia of the neurofibrillary tangle type: A comparison with Alzheimer's disease", DEMENT G C, 12(2), 2001, pp. 117-126

Abstract

A subset of senile dementia, 'senile dementia (SD) of the neurofibrillary tangle (NFT) type' (SD-NFT), is characterized by numerous NFTs in the hippocampal region and absence or scarcity of senile plaques throughout the brain, To elucidate the pathogenesis of SD-NFT in comparison with Alzheimer's disease (AD), we investigated the hippocampal lesions and analyzed the tau gene. The hippocampal regions from 5 patients with SD-NFT were neuropathologically evaluated in comparison with AD and nondemented control subjects. The tau gene was analyzed in 3 patients with SD-NFT. The densities of NFTs inthe CA1/subiculum and entorhinal cortex of SD-NFT were significantly higher than those in AD. However, hippocampal atrophy, neuronal and synaptic loss, and astrocytic and microglial proliferation in SD-NFT were significantlymild compared with AD. There was no significant difference between SD-NFT and AD in the immunoreactivities of NFTs with different anti-tau antibodies. No mutation was found in the tau gene from the SD-NFT patients. Our results indicate that the neurodegenerative process with NFT formation of the hippocampal region in SD-NFT would be different from that in AD. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 20:59:58