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Titolo:
Abnormal localization of two neuronal calcium sensor proteins, visinin-like proteins (VILIPs)-1 and -3, in neocortical brain areas of Alzheimer disease patients
Autore:
Braunewell, KH; Riederer, P; Spilker, C; Gundelfinger, ED; Bogerts, B; Bernstein, HG;
Indirizzi:
Otto Von Guericke Univ, Dept Psychiat, D-38120 Magdeburg, Germany Otto VonGuericke Univ Magdeburg Germany D-38120 8120 Magdeburg, Germany Leibniz Inst Neurobiol, Dept Neurochem Mol Biol, Magdeburg, Germany Leibniz Inst Neurobiol Magdeburg Germany m Mol Biol, Magdeburg, Germany Signal Transduct Res Grp, Magdeburg, Germany Signal Transduct Res Grp Magdeburg Germany Res Grp, Magdeburg, Germany Univ Wurzburg, Dept Psychiat, Clin Neurochem, D-8700 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-8700 eurochem, D-8700 Wurzburg, Germany
Titolo Testata:
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
fascicolo: 2, volume: 12, anno: 2001,
pagine: 110 - 116
SICI:
1420-8008(200103/04)12:2<110:ALOTNC>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
BINDING PROTEIN; IMMUNOREACTIVE CELLS; SELECTIVE LOSS; PARVALBUMIN; EXPRESSION; CALRETININ; GENE; INTERNEURONS; NEUROCALCIN; RECEPTOR;
Keywords:
calcium-sensor protein; VILIP-1 and-3; immunohistochemistry; human neocortex; Alzheimer's disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Bernstein, HG Otto Von Guericke Univ, Dept Psychiat, Leipziger Str 44, D-38120 Magdeburg, Germany Otto Von Guericke Univ Leipziger Str 44 Magdeburg Germany D-38120
Citazione:
K.H. Braunewell et al., "Abnormal localization of two neuronal calcium sensor proteins, visinin-like proteins (VILIPs)-1 and -3, in neocortical brain areas of Alzheimer disease patients", DEMENT G C, 12(2), 2001, pp. 110-116

Abstract

The anatomical distribution of the neuronal calcium sensor proteins visinin-like protein-1 and -3 (VILIP-1 and -3) was investigated in various neocortical areas of Alzheimer's disease (AD) patients and controls. In AD and normal brains their cellular localization was confined to pyramidal and non-pyramidal neurons. In AD brains the intracellular immunostaining for VILIP-1and to a lesser extent for VILIP-3 was found to be reduced in comparison to controls. Also, significantly less VILIP-1-immunoreactive neurons were found in the temporal cortex of AD patients as compared to normal brains. Accordingly, Western blot analysis revealed that immunoreactivity for VILIP-1 is less concentrated in tissue extracts of the temporal cortex of AD patients compared to controls, Extracellularly, VILIP-1 and VILIP-3 immunoreactive material was detected in close association with typical pathologic hallmarks of AD such as dystrophic nerve cell processes, amorphous and neuritic plaques, and extracellular tangles. In control brains an extraneuronal localization of VILIP-1 or VILIP-3 was never observed. Our morphological and neurochemical findings point to an involvement of these two neuronal calcium sensor proteins in pathology and possibly pathophysiology of changed calciumhomeostasis in AD. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 09:22:22