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Titolo:
SNPing in the human genome
Autore:
Carlson, CS; Newman, TL; Nickerson, DA;
Indirizzi:
Univ Washington, Dept Mol Biotechnol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ol Biotechnol, Seattle, WA 98195 USA
Titolo Testata:
CURRENT OPINION IN CHEMICAL BIOLOGY
fascicolo: 1, volume: 5, anno: 2001,
pagine: 78 - 85
SICI:
1367-5931(200102)5:1<78:SITHG>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
SINGLE-NUCLEOTIDE POLYMORPHISMS; COMMON DISEASE GENES; LINKAGE DISEQUILIBRIUM; OLIGONUCLEOTIDE PROBES; MULTIPLEX DETECTION; CANDIDATE GENES; POINT MUTATIONS; FLOW-CYTOMETRY; DNA VARIATIONS; BASE CHANGES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Carlson, CS Univ Washington, Dept Mol Biotechnol, Box 357330, Seattle, WA 98195 USA Univ Washington Box 357330 Seattle WA USA 98195 , WA 98195 USA
Citazione:
C.S. Carlson et al., "SNPing in the human genome", CURR OP C B, 5(1), 2001, pp. 78-85

Abstract

More than a million genetic markers in the form of single nucleotide polymorphisms are now available for use in genotype-phenotype studies in humans. The application of new strategies for representational cloning and sequencing from genomes combined with the mining of high-quality sequence variations in clone overlaps of genomic and/or cDNA sequences has played an important role in generating this new resource. The focus of variation analysis isnow shifting from the identification of new markers to their typing in populations, and novel typing strategies are rapidly emerging. Assay readouts on oligonucleotide arrays, in microtiter plates, gels, flow cytometers and mass spectrometers have all been developed, but decreasing cost and increasing throughput of DNA typing remain key if high-density genetic maps are tobe applied on a large scale.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:28:08