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Titolo:
Decreased reuptake of serotonin in human platelets after surgery
Autore:
Naesh, O; Hindberg, I; Bruun, AB;
Indirizzi:
Herlev Hosp, Dept Anaesthesiol, Copenhagen, Denmark Herlev Hosp Copenhagen Denmark , Dept Anaesthesiol, Copenhagen, Denmark Frederiksberg Hosp, Dept Clin Chem, Copenhagen, Denmark Frederiksberg Hosp Copenhagen Denmark pt Clin Chem, Copenhagen, Denmark
Titolo Testata:
CLINICAL PHYSIOLOGY
fascicolo: 1, volume: 21, anno: 2001,
pagine: 39 - 43
SICI:
0144-5979(200101)21:1<39:DROSIH>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
STRESS-RESPONSE; SURGICAL STRESS; BLOOD-PLATELETS; DEPRESSION; ANESTHESIA; ACTIVATION; ANXIETY; RELEASE;
Keywords:
5-hydroxytryptamine; platelet physiology; stress response; surgical stress; thrombocytes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Naesh, O Univ Lund Hosp, Dept Anaesthesiol, S-22362 Lund, Sweden Univ LundHosp Lund Sweden S-22362 hesiol, S-22362 Lund, Sweden
Citazione:
O. Naesh et al., "Decreased reuptake of serotonin in human platelets after surgery", CLIN PHYSL, 21(1), 2001, pp. 39-43

Abstract

We have documented earlier a decrease in platelet serotonin and a concurrent increase in plasma serotonin, 5-hydroxytryptamin (5-HT) after various forms of stress, suggesting a disturbed platelet 5-HT reuptake mechanism following stress. In order to further elucidate these findings, we have studiedplatelet 5-HT reuptake kinetics (V-max and K-m) in nine patients before and 4 days after major, uncomplicated abdominal surgery. We found a significant decrease in the maximal 5-HT reuptake velocity (V-max) after surgery andchanges in K-m, verifying alterations in the affinity of the platelet 5-HTtransport system. The present results thus confirm the hypothesis that 5-HT reuptake kinetics are altered following adrenergic hyperactivity. A decrease in platelet 5-HT reuptake may bear implications for our understanding of poststress adaptive changes in the cardiovascular system as well as in the central nervous system (CNS) serotonergic neurones following stressful stimulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/02/20 alle ore 05:14:48