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Titolo:
Factor structure and ammonia-related modulation of the human retinal oscillatory potentials
Autore:
Beelke, M; Carozzo, S; De Carli, F; Massimilla, S; Nobili, L; Ogliastro, C; Sannita, WG;
Indirizzi:
Univ Genoa, Osped San Martino Genova, DISMR Neurophysiopathol, Ctr Neuropsychoact Drugs, I-16132 Genoa, Italy Univ Genoa Genoa Italy I-16132 europsychoact Drugs, I-16132 Genoa, Italy Natl Res Council, Ctr Cerebral Neurophysiol, Genoa, Italy Natl Res Council Genoa Italy l, Ctr Cerebral Neurophysiol, Genoa, Italy SUNY Stony Brook, Dept Psychiat & Behav Sci, Stony Brook, NY 11794 USA SUNY Stony Brook Stony Brook NY USA 11794 Sci, Stony Brook, NY 11794 USA
Titolo Testata:
CLINICAL NEUROPHYSIOLOGY
fascicolo: 2, volume: 112, anno: 2001,
pagine: 344 - 350
SICI:
1388-2457(200102)112:2<344:FSAAMO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
VISUAL EVOKED-POTENTIALS; HEPATIC-ENCEPHALOPATHY; SYNAPTIC TRANSMISSION; SODIUM VALPROATE; PYRAMIDAL CELLS; GLUCOSE; CONE; ELECTRORETINOGRAM; SYSTEM; ROD;
Keywords:
electroretinogram; retinal oscillatory potential; plasma ammonia; healthy volunteers; factor analysis; correlation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Sannita, WG Univ Genoa, Osped San Martino Genova, DISMR Neurophysiopathol,Ctr Neuropsychoact Drugs, Largo R Benzi 10, I-16132 Genoa, Italy Univ Genoa Largo R Benzi 10 Genoa Italy I-16132 Genoa, Italy
Citazione:
M. Beelke et al., "Factor structure and ammonia-related modulation of the human retinal oscillatory potentials", CLIN NEU, 112(2), 2001, pp. 344-350

Abstract

Objective: To investigate in man the factor structure of retinal oscillatory potentials (OPs) to full-field luminance stimulation (0.9-9.5 cd.s.m(-2)) and the correlation with the spontaneous fluctuations of plasma ammonia. Methods: Six male healthy volunteers were studied. Five OP recordings and ammonia determinations (GLDH method) were obtained for each subject at 2 h interval during an 8 h experimental session. A standard factor analysis wasapplied on the OP latency (time from stimulus to peak) and amplitudes values. Results: Two consecutive factors on latencies and two factors on amplitudes were identified. consistent with reported differences between the earlierand later OP waves. The model explained a large portion of the OP variance. Both factors on latencies and factor 1 on amplitudes were directly correlated to the stimulus intensity and the ammonia plasma concentration in the 15.8-39.5 mu mol/l range. Factors 1 and 2 on latencies decreased and factor1 on amplitude increased at increasing stimulus intensities. The latency factors decreased and the amplitude factor increased with increasing ammoniaconcentration. Factor 2 on amplitudes did not correlate with the stimulus intensity or ammonia concentration. Conclusions: The factor structure further supports the evidence of functional differences between early and late OP waves. The observed correlation conceivably reflects a role of ammonia in the modulation of retinal electrophysiology in physiological conditions and potentially accounts for spontaneous variability in otherwise controlled electrophysiological studies. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

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Documento generato il 28/03/20 alle ore 22:59:03